Reaction, allergic

C. It is secreted along with noradrenaline by the adrenal medulla, from which it may be obtained. It may be synthesized from catechol. It is used as the acid tartrate in the treatment of allergic reactions and circulatory collapse. It is included in some local anaesthetic injections in order to constrict blood vessels locally and slow the disappearance of anaesthetic from the site of injection. Ultimately it induces cellular activation of phosphorylase which promotes catabolism of glycogen to glucose. 

It is a powerful antagonist of histamine, antagonizing its effect on smooth muscle of the bronchioles, bladder and partially the intestines and preventing the dilation of capillaries. Promethazine is used in the treatment of allergic reactions. 

Health and safety information is available from the manufacturer of every adhesive sold in the United States. The toxicology of a particular adhesive is dependent upon its components, which mn the gamut of polymeric materials from natural products which often exhibit low toxicity to isocyanates which can cause severe allergic reactions. Toxicological information may be found in articles discussing the manufacture of the specific chemical compounds that comprise the adhesives. 

Sulfites and related compounds have been the subject of much controversy. It has been shown that these chemicals may cause serious allergic reactions in sensitive individuals. In the United States, sulfite-containing foods must be labeled as such, and sulfites ate prohibited in areas such as salad bats where labeling is inappropriate. 

History. Methods for the fractionation of plasma were developed as a contribution to the U.S. war effort in the 1940s (2). Following pubHcation of a seminal treatise on the physical chemistry of proteins (3), a research group was estabUshed which was subsequendy commissioned to develop a blood volume expander for the treatment of military casualties. Process methods were developed for the preparation of a stable, physiologically acceptable solution of alburnin [103218-45-7] the principal osmotic protein in blood. Eady preparations, derived from equine and bovine plasma, caused allergic reactions when tested in humans and were replaced by products obtained from human plasma (4). Process studies were stiU being carried out in the pilot-plant laboratory at Harvard in December 1941 when the small supply of experimental product was mshed to Hawaii to treat casualties at the U.S. naval base at Pead Harbor. On January 5, 1942 the decision was made to embark on large-scale manufacture at a number of U.S. pharmaceutical plants (4,5). 

Skin. The skin may become contaminated accidentally or, in some cases, materials may be deHberately appHed. Skin is a principal route of exposure in the industrial environment. Local effects that are produced include acute or chronic inflammation, allergic reactions, and neoplasia. The skin may also act as a significant route for the absorption of systemicaHy toxic materials. Eactors influencing the amount of material absorbed include the site of contamination, integrity of the skin, temperature, formulation of the material, and physicochemical characteristics, including charge, molecular weight, and hydrophilic and lipophilic characteristics. Determinants of percutaneous absorption and toxicity have been reviewed (32—35,42,43,46—49). 

Vanillin is known to cause allergic reactions in people previously sensiti2ed to balsam of Pern, ben2oic acid, orange peel, cinnamon, and clove, but vanillin itself is not an allergic sensiti2er. 

The cephalosporins generally cause few side effects (80,132,219—221). Thrombophlebitis occurs as a result of intravenous administration of all cephalosporins. Hypersensitivity reactions related to the cephalosporins are the most common side effects observed, but these are less common than found with the penicillins. Clinically only about 5—10% of patients with allergic reactions to the penicillins manifest the same reactions to the cephalosporins, and data would contradict any tme cross-reactivity to cephalosporins in patients who have previously reacted to penicillin (80,132,219). 

The penicillins in general, ate renowned for their lack of toxicity. The most common adverse effect of the use of penicillins is an allergic reaction which can change from a mild rash to fatal anaphylactic shock in rate cases. AH penicillins cross the placenta and ate excreted in maternal milk. However, the relative freedom from toxicity tenders these compounds valuable agents during pregnancy and lactation. 

Frequendy, the treatment of helminthic diseases requites adjunct medication. Allergic reactions are commonly seen as a result of tissue invasion by worms or as a consequence of anthelmintic therapy. Antihistamines and corticosteroids may be necessary adjuncts to therapy. Anemia, indigestion, and secondary bacterial infections can also occur and may requite concomitant therapy with hematopoietic drugs and appropriate antibiotics. 

Adverse reactions to digoxin include anorexia, vomiting, diarrhea, dizziness, headaches, visual disturbances, and cardiac arrhythmias. Allergic reaction such as urticaria, skin emptions, fever, and edema have been reported (87). 

Prolonged contact with certain chromium compounds may produce allergic reactions and dermatitis in some individuals (114). The initial response is usually caused by exposure to Cr(VI) compounds, but once the allergy is estabUshed, it is extended to the trivalent compounds (111,115). There is also limited evidence of possible chromium associated occupational asthma, but there is insufficient data to estimate a dose for assumed chromium-induced asthma. Reference 116 provides a summary and discussion of chromium hypersensitivity. 

The property most frequently cited in connection with the use of Ti dental or medical appHances is titanium s unique biocompatibiHty. This helps practitioners avoid occasional allergic reactions that occur with nickel or chromium alloys, and removes concerns about the toxic or carcinogenic potential of appHances that contain nickel, chromium, or beryUium. Wrought alloys of titanium are used for orthodontic wires because of their unique elastic... 

Dipped Goods. Gloves with and without cloth support are a typical example. Unsupported appUcations involve specialty medical gloves and weather balloons. Eor CR to compete with less expensive natural mbber, it must provide added value. Natural mbber medical examination gloves contain proteins that can cause an allergic reaction in both patients and medical personnel. Polychloroprene gloves avoid the problem for those individuals, but are too expensive for general use. Natural mbber weather balloons have less lift than CR balloons and are rapidly attacked by ozone in the upper atmosphere. 

Tetracycline antibiotics have found wide application in animal industries for treatment, preventive maintenance and stimulation of growth of large horned livestock owing to what their residue amounts can be present at milk and meat of animals. Residue amounts of antibiotics are not toxic, however, capable to cause allergic reactions and to promote development of tolerance of the some people pathogenic bacterias. According with the legislative requirements of a number of the European countries it is forbidden to deliver to the population production polluted residual contents of tetracyclines. 

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