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Tributyltin acetate, toxicity

Triethyltin acetate is the most toxic organotin compound to mammals with a LD50 rat = 4 mg/kg." For comparison, the tributyltin acetate has a LD50 of -400 mg/kg." In general, the toxicity cutoff for mammals is at the butyltin, with longer chains relatively nontoxic and shorter chains somewhat toxic. ... [Pg.58]

Two types of tin derivatives have been used mainly to achieve these reactions dialkylstannylene acetals are formed by reaction of dialkyltin oxides with diols tributyltin ethers are formed by reaction of bis(tributyltin) oxide with alcohols. Some aspects of the regioselectivity achieved with these two types of intermediates are the same, while others are different, as will be outlined in the sections to follow. Where the reaction outcomes are similar, the dialkyltin reagents are strongly preferred because of their lower toxicity. As these reagents are heavily employed, the topic has been reviewed several times, but siguilicant uew observatious continue to be made. This chapter is not intended to be a comprehensive summary of all applicatious of these intermediates, but will highlight examples of each type of selectivity. [Pg.497]

In terms of ability to affect normal development of embryos of tbe horseshoe crab (Limulus polyphemus), mercury - as the acetate or chloride - was the most toxic metal tested followed in decreasing order by tributyltin chloride, hexavalent chromium, cadmium, copper, lead, and zinc. Mercury was associated with a high frequency of segment-defective embryos and could be replicated with SH inhibitors, and by compounds inhibiting SH-SS exchange. [Pg.449]


See other pages where Tributyltin acetate, toxicity is mentioned: [Pg.71]    [Pg.893]    [Pg.1198]    [Pg.71]    [Pg.407]    [Pg.407]    [Pg.1687]    [Pg.1687]    [Pg.17]    [Pg.214]    [Pg.209]    [Pg.104]    [Pg.5053]    [Pg.617]   
See also in sourсe #XX -- [ Pg.1687 ]

See also in sourсe #XX -- [ Pg.1687 ]




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