Potassium t-butylate

Sodium salt with a trace of potassium-t.-butylate. 2) tert. butylate used as base. 

Certain Schiff bases, i.e. 122, were synthesized as model compounds for Latia luciferin. This compound exhibits strong blue chemiluminescence ( max 385 nm) on oxidation with oxygen in DMSO/potassium t.-butylate, the main products being acetone and 2-formamido pyridine 124. The mechanism suggested by Me Capra and Wrigglesworth includes the concerted bond cleavage of a dioxetane derivative 123. 

Exposure of the heteroannulenes to nucleophiles has been limited largely to the purpose of stripping a suitably N- substituted azaannulene of its substituent (78AHC(23)55). Thus, nine-, 13- and 17-membered urethanes (2a), (5a), (35), (36b) and (59)-(61) were readily converted to the corresponding azaannulenides on exposure to potassium t- butylate at subzero temperatures while 13-membered acetamide (36a) afforded the desired anion (37b) on mild subzero treatment with methyllithium. 

Compound 403 is readily reduced with sodium borohydride at -78°C and yields the monoalcohol 405 (115). It also reacts with potassium t -butyl hydroperoxide at -20°C and gives the cis-enone-perester carbonate 406 in high yield (116). This last transformation can be explained by retro-Claisen fragmentation of intermediate 407 followed by the elimination of methoxide ion from 408. It is also possible that 407 undergoes a direct stereoelectronically controlled Grob type fragmentation to compound 406. 

Bromoisatoic acid anhydride Sodium hydride Potassium t-butylate... 

Separately, 3.0 g (27.1 mmol) of potassium t-butylate are dissolved in 9.0 ml of dry dimethylformamide, cooled in an acetone/dry-ice bath, treated with 3.9 g (27.1 mmol) of t-butyl isocyanoacetate and the solution obtained is added dropwise at -15°C to the mixture obtained according to the preceding paragraph. The mixture is warmed to 15°C, neutralized with 1.5 ml of glacial acetic acid, poured into 100 ml of water and extracted four times with methylene chloride. The methylene chloride solution is washed twice with water, dried over magnesium sulfate, evaporated and the crude product obtained is chromatographed on silica gel using ethyl acetate for the elution. By recrystallization from ethyl acetate/n-hexane there is obtained t-butyl (S)-8-bromo-ll,12,13,13a-tetrahydro-9-oxo-9H-imidazo[l,5-a]pyrrolo[2,l-c] [ 1,4] benzodiazepine-1-carboxylate. 

Fluoroisatoic acid anhydride Potassium t-butylate Ethyl isocyanoacetate... 

A solution of 6.5 g (32 mmol) of 7-fluoro-3,4-dihydro-4-methyl-2H-l,4-benzodiazepine-2,5(lH)-dione in 30 ml of dry dimethylformamide is treated with 4.3 g (38 mmol) of potassium t-butylate under an argon atmosphere. 

The product from Step 4 (0.130 mol), 205 ml of isopropyl alcohol and potassium t-butylate (0.156 mol) were mixed, transferred into a 380 ml stirred stainless steel autoclave, and 4.0 ml of the prepared ruthenium asymmetric catalyst solution added. The mixture was hydrogenated at ambient temperature at 4 x 10 Pa 3 hours. Thereafter, the mixture was filtered, concentrated, and the residue dissolved in a water/ethyl acetate mixture. It was treated with a 5% NH4CI solution and the organic phase dried. HPLC analysis of an aliquot indicated that the cis/trans product ratio was 99 1, respectively, with an enantiomeric excess of (S,S)-cis-l,4-dibenzyl-piperidin-3-ol of 91%. 

Interesting rearrangements have been observed when the phenylnitromethane anion is added to 2,4,6-arylated pyrylium salts. A sensitive intermediate, probably the dihydrobenzene derivative 1 was isolated from 2,6-diphenyl-4-(p-tolyl)-pyrylium-tetrafluoroborate and phenylnitromethane in t-butanol with only one mole potassium-t-butylate. When heated in toluene, the dihydrobenzene derivative 2 which is sub-... 

Triphenyl-pyrylium salts and ring substituted phenylnitromethane derivatives similarly rearrange to the phenols 6 or nitrobenzenes 7. When the ringsubstituted phenylnitromethane is reacted with the 2,4,6-arylated pyrylium salt in t-butanol with one mole of potassium t-butylate, 5 is the suspected intermediate. It rearranges to the phenol 6 when heated in 1,2-dichlorobenzene with one mole of ethyl-diisopropylamine and to the nitro compound 7 with an excess of potassium t-butylation in t-butanol (47-81 % yield l38). Some similar examples are shown in Table 1. 

When 2,4,6-tri- or 2,3,4,6-tetraarylated pyrylium tetrafluoroborate is treated with nitromethane under different conditions rearrangement is also observed. No rearrangement occurs when the two components are heated together with an excess of potassium t-butylate in t-butanol (route a). Under strong basic conditions the intermediate 11 probably loses the acidic proton at position 1 to give the aromatic nitro compound 12. 

In case of the direct reaction of the natural oil or lower alkyl ester of natural fatty acid and the amine the reaction method for producing the amide derivatives is as follows That is, about 1 mol of the said oils and 1 to 100 equivalent mols of the said amines are mixed in the absence or presence of solvents such alcohols as methanol, ethanol or the like, such aromatic hydrocarbons as benzene, toluene, xylene or the like, such halogenoalkanes as methylene chloride, chloroform, carbon tetrachloride or the like, and such alkenes or alkanes as petroleum ether, benzene, gasoline, ligroin or cyclohexane, such ethers as tetrahyrofuran, dioxane and the like, or a mixture thereof, and the mixture is subjected to the reaction in the absence or presence of catalyst amount or equimolar amount to the amine of an auxiliary agent of condensation, such as alkoholate of alkali metal, i.e. lithium, methylate, lithium ethylate, sodium methylate, sodium ethylate, potassium-t-butylate and the like, or acidic auxiliary agents, i.e. p-toluenesulfonic acid and the like, thereby to yield the amide derivatives. In this reaction, a formal alcohol may be removed from the reaction system. 

MgAl hydrotalcite impregnated with potassium t-butylate has recently been used for aldolization reactions [35]. The results are summarized in Table 4 for the condensation of acetone on benzaldehydes of general formula R2CHO. 

Reaction of (169) with potassium t-butylate in THE followed by acidic workup affords hexa-hydropyridazinone (170) (Equation (18)) <94S66>. 

Precaution Flamm. dangerous fire hazard exposed to flame mod. explosive when exposed to flame incompat. with strong oxidizers (increases fire risk), strong acids or strong bases (decomp, can occur), potassium t-butylate (ignition can occur)... 

K Sodium Silicate. See Sodium silicate KSS. See Potassium diphenylsulfone sulfonate KTB. See Potassium t-butylate K-Tea. See Copper-triethanolamine complex KTPP. See Potassium tripolyphosphate Kukui (Aleurites moluccana) nut oil CAS 8015-80-3 EINECS/ELINCS 273-313-5 Synonyms Aleurites moluccana Aleurites... 

Potassium t-butoxide. See Potassium t-butylate Potassium t-butylate CAS 865-47-4... 

Potassium t-butylate C4H10N 2HCI Piperazine dihydrochloride... 

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