Material safety data sheet review

AH Department of Transportation (DOT), Environmental Protection Agency (EPA), and Occupational Safety and Health Act (OSHA) rules and regulations should be reviewed prior to handling hydrochloric acid and all the regulations must be followed. AH employees handling HCl must be trained to ensure that they are familiar with the appropriate materials safety data sheets and appHcable regulations. 

A brief summary of safety and health hazards follows detailed health hazards, however, should be obtained from producers by requesting Material Safety Data Sheets. Proper protective equipment and exposure hazards should be noted before handling any alkan olamine. Detailed toxicological testing is found in the CTEA Chemical Ingredient Review Board Reports on ethanolamines and isopropanolamines (24). 

Toxicity Data on Af- Vinyl-2-Pyrrolidinone. Results of a chronic inhalation study in rats warrant a review of industrial hygiene practices to assure that VP vapor concentrations are maintained at a safe level. One of the manufacturers, ISP, recommends that an appropriate workplace exposure limit be set at 0.1 ppm (vapor) (9). Additionally, normal hygienic practices and precautions are recommended, such as prompt removal from skin and avoidance of ingestion. In case of accidental eye contact, immediately flush with water for at least 15 minutes and seek medical attention. Refer to the manufacturers Material Safety Data Sheets for more detailed information. Table 3 provides some toxicity data. 

Health ha2ards linked to carbon disulfide are extensively covered (136). Also available are epidemiological studies (144—146), general reviews containing many references (147—150), and a Material Safety Data Sheet (151). 

Neady every significant class of dyes and pigments has some members that function as sensitizers. Toxicological data are often included in surveys of dyes (84), reviews of toxic substance identification programs (85), and in material safety data sheets provided by manufacturers of dyes. More specific data about toxicological properties of sensitizing dyes are contained in the Engchpedia under the specific dye classes (see Cyanine dyes Polymethine dyes Xanthene dyes). 

While material safety data sheets (MSDS) provide important information they may not provide information on all hazards that may be encountered during processing. A review of the MSDS is not a substitute for conducting a process hazards analysis. Additional information to consider should include ... 

An overall review of the management of change documentation package should be performed to ensure documentation update items (including material safety data sheets) are addressed and that PHA action items are complete. This can be done by one person but is often best achieved by a PSSR Team. The process needs to account for ... 

To determine if you have manufactured, processed, used or stored any of the materials on the lists of covered substances, you should review material safety data sheets and labels for the products that you have. If you do not have data sheets or labels for any of your products, you should contact the manufacturer or supplier to get that information. 

Industrial hygiene/toxicology people need to develop acute and chronic toxicology information on all the materials used and produced in the process. This information should also include the potential products of abnormal reactions. The industrial hygiene member of the team should be prepared to explain the toxicology information on the material safety data sheet (MSDS) to the review team. 

Before following procedures outlined in this book, readers should refer to the original references for any specific handling practice that may be cited. Material safety data sheets also should be reviewed tor any additional handling precautions. 

Review of Material Safety Data Sheets (MSDSs)... 

Pyridine and BF3 in methanol are hazardous and must be used only in a well-ventilated hood. A solvent partition after acylation helps remove residual pyridine from the sample. Material Safety Data Sheets for the derivatizing agents should be reviewed and kept readily available. 

Because of their beneficial solubilizing characteristics and role in promoting desired reactions, solvents such as 2-methoxyethanol have become widely employed in CSD processes. It should be noted, however, that such compounds frequently demonstrate adverse effects. For example, 2-methoxyethanol is a known teratogen. The reader is encouraged to always review the Material Safety Data Sheet (MSDS) for the selected solvent and starting reagents. These sheets are typically provided by the commercial vendor at the time of purchase. 

Material Safety Data Sheets, describing hazards and precautionary measures, have been produced for an equal period. Reviews of new products prior to commercialization have been mandatory in our company well before PMN rules appeared. 

Safety policies and procedures are documented, and Material Safety Data Sheets are provided for all chemicals used in the laboratory. In addition, a chemical hygiene plan that defines the safety procedures for all hazardous chemicals is written in detail. All laboratory personnel must review these policies on an annual basis. 

Cleaning materials and their methods of use can present significant and, frequently, undetected fire hazards. Any cleaning chemical or material brought into a facility should be reviewed for potential hazards using Material Safety Data Sheet (MSDS) information as a part of the material s hazard identification element of the overall fire prevention program. Cleaning activities should not be allowed to add unreasonable hazards to a facility. 

To identify other hazardous wastes in shop, the three types of the material safety data sheet (MSDS) provided by the supplier of the product should be reviewed. A plant manager can also find out the hazardous ingredients in the processing chemical and refer to the State Hazardous Waste Regulations or call the State Division of Hazardous Waste. 

Safety glasses must be worn in the laboratory at all times. Other personal protection equipment should be worn as needed, especially appropriate safety gloves. Sodium fluoride is a deadly poison if ingested full chemical precautions should be observed. Material safety data sheets (MSDS) should be reviewed before beginning the experiment. 

In addition to a review of several thousand material safety data sheets, the author consulted and... 

Most sealants use mineral-based fillers, which may contain small amounts of crystalline silica. Crystalline silica is a known cause of silicosis, a debilitating disease of the lung. Some but not all sealants use flammable ingredients, but for those that do, proper inserdng and grounding are needed to prevent potential explosions. In general, sealants should be used in areas that have good ventilation, A careful review of the material safety data sheet is fundamental before use of any sealant. 

A waste is an ignitable hazardous waste if it has a flash point of less than 60 °C, readily causes fires and burns so vigorously as to create a hazard. A simple method of determining the flash point of a waste is to review the material safety data sheet, which can be obtained from the manufacturer or distributor of the material. Naphtha, lacquer thinner, epoxy resins, adhesives, and oil based paints are all examples of ignitable hazardous wastes. 

The toxicity associated with SM is quite profound. The Army s Chemical Defense Equipment Process Action Team estimated in 1994 that a 900 mg-min/m SM vapor exposure would be lethal in 2-10 min, based on animal studies (National Research Council Review, 1997). Fortunately, in the battlefield, lethality has been limited. Only 1-3% of exposed soldiers died from SM exposure after WWI, and mortality mostly was not a direct consequence of SM, but rather the indirect effect of secondary respiratory infections. The 1999 Material Safety Data Sheet, put out by the US Army Soldier and Biological Chemical Command, USA Edgewood Chemical Biological Center, has estimated the LD50 of a skin exposure to sullur mustard as lOOmg/kg. This roughly translates into as little as 7 ml of neat SM (i.e. 8.9 g) spread over the skin resulting in the death of a 80 kg adult (Department of the Army, MSDS, 1999). The cornea, of course, is more sensitive than the skin. Below we review three chief toxic effects of severe SM exposure to the cornea. 

Locate and review the Materials Safety Data Sheet for methylisocyanate. 

We are grateful to Aspen Technology Inc. and Honeywell Inc. for permission to include the screen shots that were generated using their software to illustrate the process simulation and costing examples. Laurie Wang of Honeywell also provided valuable review comments. The material safety data sheet in Appendix I is reproduced with permission of Eischer Scientific Inc. Aspen Plus , Aspen Kbase, Aspen ICARUS,... 

Johanson G (2000) Toxicity review of ethylene glycol monomethyl ether and its acetate ester. Critical Reviews in Toxicology 30(3) 307-345. Material Safety Data Sheets may be obtained from principal suppliers of metboxyethanol. 

Safety training for wastewater supervisors and employees. Eye, ear, foot, hand, and other protective equipment maintaining safe work environment and reviewing material safety data sheets. Produced by Regional Municipality of Halton, Ontario. 

---