Renal effects, insulin-like growth factors

Renal elimination of phosphorus is regulated by PTH, calcitriol, growth hormone, insulin, and insulin-like growth factors. While the above-mentioned hormones show a number of other effects, the existence of a hormone affecting selectively the extracellular concentration of phosphorus is expected. The task of this hormone with phosphaturic effect has been speculated about from the beginning of the 1990s. It was named phosphatonin, and its increased concentration is found especially in patients with osteomalacia (tumor-induced osteomalacia, X-linked hypophosphatemic rickets, epidermal nevus). The phosphaturic effect of... 

Tonshoff B, Kaskel FJ, Moore LC Effects of insulin-like growth factor i on the renal juxtamedullary microvasculature. Am.J.Physlol 274 F120-F128,1998... 

Guler, H.-P., Schmid, C., Zapf, J. and Froesch, E.R. (1989) Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects. Proc Natl. Acad. Sci. USA 86 2868-2872. 

---