Insulin-like growth factors IGF-binding protein

A6. AngellozrNicoud, P., Harel, L., and Binoux, M., Recombinant insulin-like growth factor (IGF) binding protein-3 stimulates prostate carcinoma cell proliferation via an IGF-dependent mechanism. Role of serine proteases. Growth Regul. 6, 130-136 (1996). 

B4. Benbassat, C. A., Maki, K. C., and Unterman, T. G., Circulating levels of insulin-like growth factor (IGF) binding protein-1 and -3 in aging men Relationships to insulin, glucose, IGF, and dehydroepiandrosterone sulfate levels and anthropometric measures. J. Clin. Endocrinol. Metab. 82, 1484-1491 (1997). 

F6. Figueroa, J. A., Lee, A. V., Jackson, J. G., and Yee, D., Proliferation of cultured human prostate cells is inhibited by insulin-like growth factor (IGF) binding protein-1 Evidence for an IGF-II... 

Baxter RC. Insulin-like growth factor (IGF) binding proteins The role of serum IGFBPs in regulating IGF availability. Acta Paediatr Scand Suppl 1991 372 107-14. 

R245 R. C. Baxter, Insulin-Like Growth Factor (IGF) - Binding Proteins Interactions with IGFs and Intrinsic Bioactivities , Am. J. Physiol., 2000, 278, E967... 

Sirotkin, A.V., Makarevich, A.V., M.R. Corkins, Kotwica, J., Kwon, H.B., Bulla, J., and Hetenyi, L. (2001) Secretory Activity of Bovine Ovarian Granulosa Cells Transfected with Sense and Antisense Insulin-Like Growth Factor (IGF) Binding Protein-3 and the Response to IGF-I, GH, LH, Oxytocin and Estradiol, J. Mol. Endocrinol. 27, 329-338. 

There is only one major system of interacting growth factors and receptors in the fetus — the insulin (INS) and insulin-like growth factor (IGF) system (Table 1 and Fig. 1). Ignoring various binding proteins that modulate IGF actions in tissues and... 

Horney, M.J. et al. (2001) Synthesis and characterization of insulin-like growth factor (IGF)-l photoprobes selective for the IgG-binding proteins (IGFBPs) photoaffinity labeling of the IGF-binding domain on IGFBP-2./. Biol. Chem. 276(4), 2880-2889. 

The presence of serum-binding proteins. Some biopharmaceuticals (including insulin-like growth factor (IGF), GH and certain cytokines) are notable in that the blood contains proteins that specifically bind them. Such binding proteins can function naturally as transporters or activators, and binding can affect characteristics such as serum elimination rates. 

Kleinman D, Karas M, Danilenko M (1996) Stimulation of endometrial cancer cell growth by tamoxifen is associated with increased insulin-like growth factor (IGF)-I induced tyrosine phosphorylation and reduction of IGF binding proteins. Endocrinology 137 1089-1095... 

Guan J, WiUiams CE, Skinner SJ, Mallard EC, Gluckman PD. 1996. The effects of insulin-like growth factor (IGF)-l, IGF-2, and des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats evidence for a role for IGE binding proteins. Endocrinology 137 893-898. 

Tolins JP, Raij L (1990) Comparison of converting enzyme inhibitor and calcium channel blocker in hypertensive glomerular injury. Hypertension 10 452-461 Tonshoff B, Powell DR, Zhao D et al. (1997) Decreased hepatic insulin-like growth factor (IGF)-I and increased IGF binding protein-1 and -2 gene expression in experimental uremia. Endocrinology 138 938-946... 

A5. Angelloz-Nicoud, P., and Binoux, M., Autocrine regulation of cell proliferation by the insulin-like growth factor (IGF) and IGF binding protein-3 protease system in a human prostate carcinoma cell line (PC-3). Endocrinology 136, 5485-5492 (1995). 

Proinsulin, Insulin, Insulin-like Growth Factors (IGF), IGF-Binding Proteins,... 

The growth hormone/insulin-like growth factor (IGF) axis plays a role in ovarian responsiveness. The IGF system comprises of IGF-I and -II and their binding-proteins, IGF-binding proteins (BP)-l to -6 (G3). 

Oosterhuis, G. J. E., Vermes, I., Lambalk, C. B., Michgelsen, H. W. B., and Schoemaker, J., Insulin-like growth factor (IGF)-I and IGF binding protein-3 concentrations in fluid from human stimulated follicles. Hum. Reprod. 13,285-289 (1998). 

Insulin-like growth factors (IGF) have been shown to enhance hepatic amino acid transport as well. Actually, there are two major forms of IGF which, in the human, are called IGF-I and IGF-II. The corresponding proteins in the rat have been identified as somatomedin G and multiplication-stimulating factor (MSA). There are specific receptors for IGF-I and IGF-II in the plasma membrane of eukaryotic cells, although the IGF-I receptors show some affinity for IGF-II and vice versa (46). Furthermore, Massague and Czech (46) have shown that the IGF-I receptor exhibits some, albeit weak, affinity for insulin, whereas the IGF-II receptor does not bind insulin to a significant extent. Those authors have also demonstrated that rat liver lacks IGF-I (somatomedin C) receptors, so MSA would appear to play a more important role than somatomedin C in the regulation of hepatic metabolism in this species. 

Clemmons, D. R., W. H. Busby, T. Arai et al. 1995. Role of insulin-like growth factor binding proteins in the control of IGF actions. Prog Growth Factor Res 6(2-4) 357-366. 

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