Insulin-like growth factor-II

Petrik J, Pell JM, Arany E et al 1999 Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia. Endocrinology 140 2353-2363... 

Runge S, Nielsen FC, Nielsen J, Lykke-Andersen J, Wewer UM, Christiansen J 2000 HI 9 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein. J Biol Chem... 

Couce M, Weatherington A, McGinty JE. 1992. Expression of insulin-like growth factor-II (IGF-II) and IGE-II/Mannose-6-phosphate receptor in the rat hippocampus an in situ hybridization and immunocytochemical study. Endocrinology 131 1636-1642. 

Hawkes C, Kar S. 2003. Insulin-like growth factor-II/mannose-6-phosphate receptor widespread distribution in neurons of the central nervous system including those expressing cholinergic phenotype. J Comp Neurol 458 113-127. 

Hawkes C, Kar S. 2004. The insulin-like growth factor-II/ mannose-6-phosphate receptor structure, distribution and function in the central nervous system. Brain Res Rev 44 117-140. 

Hawkes C, Jhamandas JH, Harris K, Fu J, Mac Donald RG, et al. 2006. Single transmembrane domain insulin-like growth factor-II/mannose-6-phosphate receptor regulates central cholinergic function by activating a G-protein-sensi-tive, protein kinaseC-dependent pathway. J Neurosci 26 585-596. 

I] insulin-like growth factor II and [ I] insulin receptor binding sites in developing and adult rat brain. J Comp Neurol 333 375-397. 

Kar S, Baccichet A, Quirion R, Poirier J. 1993b. Entorhinal cortex lesion induces differential responses in [ I] insulinlike growth factor I, [ I] insulin-like growth factor II and [ I] insulin receptor binding sites in the rat hippocampal formation. Neuroscience 55 69-80. 

Kornfeld S. 1992. Structure and function of the mannose 6-phosphate/insulin-like growth factor II receptors. Annu Rev Biochem 61 307-330. 

Smith M, Clemens J, Kerchner GA, Mendelsohn LG. 1988. The insulin-like growth factor-II (IGF-II) receptor of rat brain regional distribution visualized by autoradiography. Brain Res 445 241-246. 

IGFII/M6P insulin-like growth factor II/mannose-6-phosphate receptor... 

The gene for BWS has been mapped to chromosome 11 (11 pi5), a region encompassing the gene for insulin-like growth factor II ( GV2), which is maternally imprinted and thus is expressed only when paternally inherited. 

P. J. De Bleser, C. D. Scott, T. Niki, G. Xu, E. Wisse, and A. Geerts, Insulin-like growth factor II/mannose 6-phosphate-receptor expression in liver and serum during acute CC14 intoxication in the rat, Hepatology 23 1530-1537 (1996). 

N6. Nielsen, F. C., The molecular and cellular biology of insulin-like growth factor II. Prog. Growth Factor Res. 4, 257-290 (1992). 

The N-terminal sequence of MRCH/PBAN shows some similarity to a portion of insulin-like growth factor-II, whereas the C-terminal sequence of MRCH/PBAN is nearly identical to the C-terminal pentapeptide sequence of leukopyrokinin (pGlu-Thr-Ser-Phe-Thr-Pro-Arg-... 

Sequence homology has been noted previously (17) between the N-terminus of Hez-PBAN and insulin-like growth factor II, and the C-terminus with the insect peptide leucopyrokinin (Table II) isolated from cockroach heads. The striking similarity of the first 16 residues of the melanization and reddish colorization hormone (MRCH) of B. mori (18) and Bom-PBAN has led to the suggestion by Kitamura ti 1. (17) that they are identical (Table II), thus implying a dual role for this hormone in the larvae (melanization and reddish colorization) and adult moth (pheromone biosynthesis). 

Hez-PBAN... BonhPBAN. AlRCH-1... Leucopyrokinin Insulin-like Growth Factor II... 

Yee, D., Cullen, K. J., Paik, S., Perdue, J. R, Hampton, B., Schwartz, A., Lippman, M. E. and Rosen, N. (1988). Insulin-like growth factor II mRNA expression in human breast cancer. Cancer Res. 48, 6691-6696. 

M. Costello, R. C. Baxter, and C. D. Scott, Regulation of soluble insulin-like growth factor II mannose 6-phosphate receptor in human serum Measurement by enzyme-linked immunosorbent assay, J. Clin. Endocrinol. Metab. 84 611 (1999). 

Korner C, Nurnberg B, Uhde M et al. (1995) Mannose 6-phosphate/insulin-like growth factor II receptor fails to interact with G-proteins. In J. Biol. Chem. 270 287—295... 

Souza R, Appel R, Yin J, Wang S, Smolinski KN, Abraham JM, et al. Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours. Nat Genet 1996 14 255-7. 

Backlin BM, Gessbo A, Forsberg M, et al. 1998a. Expression of the insulin-like growth factor II gene in polychlorinated biphenyl exposed female mink (mustela vison) and their fetuses. Mol Pathol 51(l) 43-7. 

Acquaviva, A. M., Bruni, C. B., Nissley, S. P., and Rechler, M. M., Cell-free synthesis of rat insulin-like growth factor II. Diabetes 31, 656-658 (1982). 

H9. Haselbacher, G., and Humbel, R., Evidence for two species of insulin-like growth factor II (IGF II and big IGF II) in human spinal fluid. Endocrinology (Baltimore) 110,1822-1824 (1982). 

H16. Hintz, R. L., and Liu, F., A radioimmunoassay for insulin-like growth factor II specific for the C-peptide region. J. Clin. Endocrinol. Metab. 54, 442-446 (1982). 

Fig. 3. Biosynthesis of Man-6-P N-linked oligosaccharides and interaction with Man-6-P receptors. This figure compares the biosynthetic pathways of Man-6-P on lysosomal enzymes in mammalian cells and in Dictyostelium discoideum. It also shows their binding to the cation-independent/insulin-like growth factor II receptor (Man-6-P/IGFII) and to the cation-dependent mammalian Man-6-P receptor. Enzymes are (1) GlcNAc-1-P transferase, (2) a-A-acetylglucosaminidase, and (3) M-6-P phosphate methyltransferase. Solid circles, Man solid squares, GlcNAc.

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