Insulin-like growth factor diabetes effects

Thrailkill KM, Fowlkes JL, Hyde JF, Litton JC. The effects of co-therapy with recombinant human insulin-like growth factor I and insulin on serum leptin levels in adolescents with type 1 diabetes mellitus. Pediatr Diabetes 2001 2(l) 25-9. 

Ishii, D.N. and Lupien, S.B. (1995) Insulin-like growth factors protect against diabetic neuropathy effects on sensory nerve regeneration in rats. J. Neurosci. Res. 40 138-144. 

Tan, K. and Baxter, R.C. (1986) Serum insulin-like growth factor I levels in adult diabetic patients the effect of age. J. Clin. Endocrinol. Metab. 63 651-655. 

Zhuang, H.-X., Snyder, C.K., Pu, S.-F. and Ishii, D.N. (1996) Insulin-like growth factors reverse or arrest diabetic neuropathy effects on hyperalgesia and impaired nerve regeneration in rats. Exp. Neurol. 140 198-205. 

It has been hypothesized that growth hormone (GH) may facilitate the progression of various disease states. These pathological effects may occur either by direct GH stimulation or indirectly by the elevation of insulin-like growth factor-1 (lGF-1). For more than 30 years, the importance of GH in the development and progression of diabetic... 

Kiritsy, C. R, Antoniades, H. N., Carlson, M. R., Beaulieu, M. T., and D andrea, M. 1995. Combination of platelet-derived growth factor-BB and insulin-like growth factor-I is more effective than platelet-derived growth factor-BB alone in stimulating complete healing of full-thickness wounds in older diabetic mice. Wound Repair Regeneration, 3, 340-350. 

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