Insuline-like growth factor

SEM = standard error of the means. IGF-I = insulin-like growth factor I. 

Insulin and Amylin. Insulin is a member of a family of related peptides, the insulin-like growth factors (IGFs), including IGF-I and IGF-II (60) and amylin (75), a 37-amino acid peptide that mimics the secretory pattern of insulin. Amylin is deficient ia type 1 diabetes meUitus but is elevated ia hyperinsulinemic states such as insulin resistance, mild glucose iatolerance, and hypertension (33). Insulin is synthesized ia pancreatic P cells from proinsulin, giving rise to the two peptide chains, 4. and B, of the insulin molecule. IGF-I and IGF-II have stmctures that are homologous to that of proinsulin (see INSULIN AND OTHER ANTIDIABETIC DRUGS). 

Insulin-like growth factor Angio tensino gen Leptin Ghrelin... 

Bouaboula, M., Perrachon, S., Milligan, L., Canatt, X., Rinaldi-Carmona, M., Portier, M., Barth, F., Calandra, B., Pecceu, F., Lupker, J., Maffrand, J.-P., Le Fur, G., and Casellas, P. (1997). A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor. J. Biol. Ckem. 272 22330-22339. 

In addition to insulin, the INSR can also bind insulin-like growth factors (IGF1 and IGF2) albeit with considerably lower affinity (2 and 3 orders of magnitude, respectively). 

Studies with fenretinide in woman with stage I breast cancer did not show an overall effect of decreasing the risk of contralateral breast cancer. A protective effect could only be observed in premenopausal women, probably due to the modulation of the insulin-like growth factor 1 (IGF-1) by fenretinide in this population. 

Insulin Desensitization Insulin Receptor Insulin Resistance Insulin Secretagogues Insulin-like Growth Factor Integrase Integrin, a 4(31 Integrin, a 4(3 7 Integrin, a IIb(3 3... 

ANF Atrial natriuretic factor IGF-I Insulin-like growth factor-I... 

Insulin-like growth factors I and II Nerve growth factor Platelet-derived growth factor Prolactin... 

ARJMANDI B H, KHALIL D A and HOLLIS B w (2002), Soy protein its effects on intestinal calcium transport, serum vitamin D and insulin-like growth factor-1 in ovariectomized rats. Calcif Tissue Int 70(6), 483-7. 

KHALIL D A, LUCAS E A, lUMA S, SMITH B J, PAYTON M E and ARJMANDI B H (2002) Soy prOteiu supplementation increases serum insulin-like growth factor-1 in young and old men but does not affect markers of bone metabolism. J Nutr 132, 2605-8. 

Karas, M. et ah. Lycopene interferes with cell cycle progression and insulin-like growth factor I signaling in mammary cancer cells, Nutr. Cancer, 36,101, 2000. 

G-CSF Granulocyte colony-stimulating factor GDP Guanosine 5 -diphosphate GEC Glomerular epithelial cell GF-1 An insulin-like growth factor GFR Glomerular filtration rate... 

Immunoglobulins A, E, G, M IgG I Immunc obulin G class 1 IgGa, Immunoglobulin G class 2a IGF-I Insulin-like growth factor Ig-SF Immunoglobulin supergene family... 

Fahrner, R.L., Lester, P.M., Blank, G.S., and Reifsnyder, D. H., Non-flammable preparative reversed-phase liquid chromatography of recombinant human insulin-like growth factor-I, ]. Chromatogr. A, 830, 127, 1999. 

Pegvisomant is indicated for patients who do not tolerate or fail other treatments or for those with extremely elevated insulin-like growth factor I levels. 

Dopamine agonists may be appropriate for patients with mildly elevated insulin-like growth factor I levels who have growth hormone and prolactin co-secreting tumors. 

Prolonged exposure to elevated growth hormone and insulin-like growth factor I levels can lead to serious complications in patients with acromegaly. Aggressively manage... 

GH, growth hormone Gl, gastrointestinal IGF-I, insulin-like growth factor I IM, intramuscularly LAR, long-acting release MRI, magnetic resonance imaging SQ, subcutaneously. 

IGFBP-3 insulin-like growth factor binding protein 3... 

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