Insulin-like growth factor tissue

ARJMANDI B H, KHALIL D A and HOLLIS B w (2002), Soy protein its effects on intestinal calcium transport, serum vitamin D and insulin-like growth factor-1 in ovariectomized rats. Calcif Tissue Int 70(6), 483-7. 

There is only one major system of interacting growth factors and receptors in the fetus — the insulin (INS) and insulin-like growth factor (IGF) system (Table 1 and Fig. 1). Ignoring various binding proteins that modulate IGF actions in tissues and... 

Insulin-like growth factor I (IGF-I) has a well recognized role as a trophic and survival factor for nervous system cells in tissue culture [26]. However, its specific functions in the developing and mature nervous system have been difficult to define largely because its actions as a trophic... 

Most athletes have heard of IGF-1 (Insulin like growth factor-1) and the amazing anabolic effects it has been reported to have upon protein based tissue such as muscle. Des (1-3) IGF-1 is over 10 times (1000%) more anabolic than IGF-1. Now that is amazing ... 

Growth hormone is a peptide hormone produced by the anterior pituitary. It produces growth at open epiphyses via stimulation of insulin-like growth factor I (IGF-I, somatomedin C). It also causes lipolysis in adipose tissue and growth of skeletal muscle. 

Daughaday WH, Rotwein P (1989), Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations, Endocr. Rev. 10 68-91. 

In addition to these various actions on rather general metabolic functions, GH also has some very specific effects. It has a general stimulatory effect on protein synthesis but also stimulates synthesis of some proteins selectively. Predominant among these is somatomedin C/insulin-like growth factor I (Sm-C/IGF-I), production of which is stimulated markedly in many tissues, especially the liver [13,16]. 

Bai JPF (1995) The involvement of cytosolic chymotrypsin-like, trypsin-like, and cucumsin-like activities in degradation of insulin-like growth factor I by epithelial tissue. J Pharm Pharmacol 47 674—677... 

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