Granulocyte colony-stimulating factors ,

G-CSF is also known as pluripoietin and CSI -fl. Two slight variants are known, one consisting of 174 amino acids and the other of 177. The smaller polypeptide predominates and also displays significantly greater biological activity than the larger variant. [Pg.269]

The G-CSF receptor has been well characterized. It is a single transmembrane polypeptide found on the surface of neutrophils, as well as in various haemopoietic precursor cells, platelets, endothelial cells and, notably, various myeloid leukaemias. (Myeloid means derived from bone marrow leukaemia refers to a cancerous condition in which there is uncontrolled overproduction of white blood cells in the bone marrow or other blood-forming organs. The white cells produced are generally immature/abnormal and result in the suppression of production of healthy white blood cells.) [Pg.269]

Armitage JO (1998) Emerging applications of recombinant human granulocyte colony-stimulating factor. Blood 92 4491-4508... [Pg.581]

Granulocyte colony stimulating factor 127 amino acids E. coll Adjunct to cancer chemotherapy Approved for sale By stimulating white blood cell formation, aids recovery... [Pg.464]

G-CSF Granulocyte colony-stimulating factor GDP Guanosine 5 -diphosphate GEC Glomerular epithelial cell GF-1 An insulin-like growth factor GFR Glomerular filtration rate... [Pg.282]

Neutropenia associated with interferon or pegylated interferon therapy is defined as an absolute neutrophil count (ANC) of less than 1000 cells/mm3 in rare cases, an ANC less than 500 cells/mm3 maybe observed. The neutropenia is more common and in some cases more severe with pegylated interferon than with unmodified interferon. Neutropenia usually occurs within the first 2 weeks after initiating either formulation of interferon, with the WBC count stabilizing by week four or six. The neutropenia is reversible upon discontinuing therapy. Granulocyte colony-stimulating factor has been used as an adjunctive therapy for interferon-induced neutropenia in hepatitis patients.44... [Pg.356]

GCSF, granulocyte colony stimulating factor GMCSF, granulocyte-macrophage colony stimulating factor SQ, subcutaneous IV, intravenous AML, acute myeloid leukemia. [Pg.1471]

G-CSF Granulocyte colony-stimulating factor HS At bedtime horn somni)... [Pg.1555]

Lloyd AR, Biragyn A, Johnston JA, et al. Granulocyte-colony stimulating factor and lipopolysaccharide regulate the expression of interleukin 8 receptors on polymorphonuclear leukocytes. J Biol Chem 1995 270 28188-28192. [Pg.83]

Sato N, Sawada K, Takahashi TA, et al. A time course study for optimal harvest of peripheral blood progenitor cells by granulocyte colony-stimulating factor in healthy volunteers. Exp Hematol 1994 22 973-978. [Pg.85]

Molineux G, Pojda Z, Hampson IN, Lord BI, Dexter TM. Transplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor. [Pg.131]

Levesque JP, Hendy J, Takamatsu Y, Williams B, Winkler IG, Simmons PJ. Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment. Exp Hematol 2002 30(5) 440-449. [Pg.134]

Thomas J, Liu F, Link DC. Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor. Curr Opin Hematol 2002 9(3) 183-189. [Pg.134]

Gaertner, H.F., Offord, R.E., Cotton, R., Timms, D., Camble, R., and Rose, K. (1994) Chemo-enzymic backbone engineering of proteins. Site-specific incorporation of synthetic peptides that mimic the 64-74 disulfide loop of granulocyte colony-stimulating factor. J. Biol. Chem. 269, 7224-7230. [Pg.1064]

G-CSP—granulocyte colony-stimulating factor GDP-GTP—guanine diphosphate and triphosphate GERD—-gastroesophageal reflux disease G1—gastrointestinal... [Pg.284]

Duarte, R. and Frank, D. 2002. The synergy between stem cell factor (SCF) and granulocyte colony stimulating factor (G-CSF) molecular basis and clinical relevance. Leukaemia and Lymphoma 43(6), 1179-1187. [Pg.288]

Esser, M. and Brunner, H. 2003. Economic evaluations of granulocyte colony stimulating factor in the prevention and treatment of chemotherapy-induced neutropenia. Pharmacoeconomics 21(18), 1295-1313. [Pg.288]

Tabbara, I. A., Ghazal, C.D., and Ghazal, H.H. 1996. The clinical applications of granulocyte-colony-stimulating factor in haematopoietic stem cell transplantation a review. Anticancer Research 16(6B), 3901-3905. [Pg.288]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...