Human carcinoma

Eupatin (69, R = H) and Eupatoretin (69, R = CH3), which are isolated from thistle perennials, show moderate cytotoxicity against human carcinoma of the nasopharynx (236). Baicaleia (70) salts exhibit antiallergic and antiinflammatory activity. 3,4,5-Trimethoxyphenoxyacetamides are hypotensives and diuretics and are useful for controlling arrhythmia duting anesthesia (237). 

Systemic targeting of pDNA and siRNA polyplexes has been demonstrated in several animal models. In continuation of the work with localized antiproliferative and immunostimulatory poly(I C) RNA, intravenous systemic delivery of EGER-targeted PEG-modified polyplexes were successfully used for human carcinoma treatment in mice [225]. The therapeutic effect was most pronounced when intravenous delivery of poly(I C) polyplexes was followed by intraperitoneal injection of peripheral blood mononuclear cells [226]. This induced the complete cure of SCID mice with pre-established disseminated EGFR-overexpressing tumors, without adverse toxic effects. Due to the chemokines produced by the internalized poly (I C) in the tumor cells, the immune cells home to the tumors of the treated animal and contribute to the tumor destruction. 

Trail, P.A., Willner, D., Lasch, S.J., Henderson, A.J., Hofstead, S., Casazza, A.M., Firestone, R.A., Hellstrom, I., and Hellstrom, K.E. (1993) Cure of xenografted human carcinomas by BR96-doxoru-bicin immunoconjugates. Science 261, 212-215. 

Cytotoxicity has been evaluated against the cell culture KB of the human carcinoma of the nasopharynx and lymphocyte carcinoma of the mouse P388. Alkaloids tested are reported in Table XII. These data indicate that dimeric... 

The antitumor activity of titanocene dichloride 21 was first recognized in 1979 (150), and since then the activity of several other metallocenes (V, Nb, Mo, Fe, Ge, and Sn) has been reported (151). Most interest has centered on titanocene dichloride and on vanadocene dichloride 22, which are active against a diverse range of human carcinomas, including gastrointestinal and breast carcinomas, but not against head and neck cancers. There appears to be a lack of crossresistance between titanocene dichloride and cisplatin. 

Moll R, Franke WW, Vole Platzer B, Krepler R (1982b) Different keratin polypeptides in epider mis and other epithelia of human skin a specific cytokeratin of molecular weight 46,000 in epithelia of the pilosebaceous tract and basal cell epitheliomas. J Cell Biol 95(1) 285 295 Moll R, Krepler R, Franke WW (1983) Complex cytokeratin polypeptide patterns observed in certain human carcinomas. Differentiation 23(3) 256 269 Moll R, Dhouailly D, Sun TT (1989) Expression of keratin 5 as a distinctive feature of epithelial and biphasic mesotheliomas. An immunohistochemical study using monoclonal antibody AE14. Virchows Arch B Cell Pathol Incl Mol Pathol 58(2) 129 145 Moll R, Schiller DL, Franke WW (1990) Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns. J Cell Biol 111(2) 567 580... 

Moll R, Lowe A, Laufer J, Franke WW (1992) Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies. Am J Pathol 140 427 447 Moll R, Divo M, Langbein L (2008) The human keratins biology and pathology. Histochem Cell Biol 129 705 733... 

Vallee, B. L., Isolation and characterization of angiogenin, an angiogenic protein from human carcinomas cells. Biochemistry 24, 5480-5486 (1985). 

Alvarez MG, Prucca C, Milanesio ME, Durantini EN, Rivarola V (2006) Photodynamic activity of a new sensitizer derived from porphyrin-C60 dyad and its biological consequences in a human carcinoma cell line. Int J Biochem Cell Biol 38 2092-2101. 

Strahl BD, Allis CD (2000) The language of covalent histone modifications. Nature 403 41-45 Suganuma T, Kawabata M, Ohshima T, Ikeda MA (2002) Growth suppression of human carcinoma cells by reintroduction of the p300 coactivator. Proc Natl Acad Sci USA 99 13073-13078 Timmermann S, Lehrmann H, Polesskaya A, Harel-Bellan A (2001) Histone acetylation and disease. Cell Mol Life Sci 58 728-736... 

West MA, Bretscher MS, Watts C. Distinct endocytotic pathways in epidermal growth factor-stimulated human carcinoma A431 cells. J Cell Biol 1989 109(6 Pt l) 2731-2739. 

Bhatia N, Zhao J, Wolf DM, Agarwal R. (1999) Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle Comparison with silymarin. Cancer Lett 147 77-84. 

The immunoconjugate of doxorubicin with a chimeric anti-Le -related, tumour-associated antigen expressed on most human carcinomas, was evaluated in phase I [132] and phase II [133] clinical trials. The phase II trial performed in patients with metastatic breast carcinoma showed low clinical response rates. These data together with tumour biopsy analysis suggest that the dose that could be safely administered was insufficient to maintain the intra-tu-... 

Klapper, L. N., S. Glathe, N. Vaisman, N. E. Hynes, G. C. Andrews, M. Sela, and Y. Yarden. The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors. Proc Natl Acad Sci USA. 96 4995-5000.1999. 

Smalley SR, Kinder BF, Evans RG. 5-fluorouracil modulation of radiosensitivity in cultured human carcinoma cells. Int J Radial Oncol Biol Phys 1991 20 207-211. 

Schmidt W, Chaney SG. Role of carrier ligand in platinum resistance of human carcinoma cell lines. Cancer Res 1993 53 799-805. 

Kim JH, KimSH, Kolozsvary A, KhilMS. Potentiation of radiation response in human carcinoma cells in vitro and murine fibrosarcoma in vivo by topotecan, an inhibitor of DNA topoisomerase I. Int J Radiat Oncol Biol Phys 1992 22(3) 515-518. 

Faroni RE and DeCupis A. The role of polypeptide growth factors in human carcinomas New targets for a novel pharmacological approach. Pharmacol Rev 2000 52 179-206. 

Some of the resulting compounds, in particular the 22(S)-hydroxy-falecalcitriol, exhibit an excellent selectivity, with a very high activity on human carcinoma lines (HT-29) and no calcemic effect, as assessed in vivo on rats [156],... 

N. M. S. Al-Saffar, H. Troy, A. Ramirez de Molina, L. E. Jackson, B. Madhu, J. R. Griffiths, M. O. Leach, P. Workman, J. C. Lacal, 1. R. Judson and Y.-L. Chung, Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models. Cancer Res., 2006,66,427-434. 

Perillyl alcohol induced apoptosis and was more effective than perillaldehyde at inhibiting the proliferation of human carcinoma cell lines cultured in vitro [319]. Perillyl alcohol treatments suppressed cell growth [313-315], reduced cyclin D1 RNA and protein levels and prevented the formation of active cyclin D1 associated with kinase complexes in synchronous cells during the exit of GO and entry into the cell cycle [284, 316, 317]. In addition, perillyl alcohol treatment induced an increased association of p21 [316-318] with cyclin E-Gdk2 complexes, inhibited the activating phosphorylation of Gdk2 [312, 316, 318-320], initiated apoptosis [321-324] and suppressed small G-protein isoprenylation... 

Irciniasulfonic acid (629) was obtained from Ircinia sp. from Japanese waters. Spectroscopic and chemical analyses revealed it to consist of three different kinds of acids common fatty acids, a novel unsaturated branched CIO fatty acid and an isethionic acid. Irciniasulfonic acid (629) reverses multidrug resistance in human carcinoma cells caused by overexpression of membrane glycoprotein [498]. 

Milenic, D. E, Estaban, J. M., and Colcher, D. (1989) Comparison of methods for the generation of lmmunoreactive fragments of a monoclonal-antibody (B72.3) reactive with human carcinomas. J. Immunol Methods 120, 71—83. 

Ahmad, N., Feyes, D. K., Nieminen, A.-L., Agarwal, R., and Mukhtar, H., 1997, Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells, J. Natl. Cancer Inst. 89 1881-1886. 

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