Human lung carcinoma

The two aliphatic amino acids have also been replaced by the hydrophobic spacers 3-(aminomethyl)benzoic acid (3-AMBA see 9, Fig. 2) [28] and 3- and 4-aminobenzoic acid (3- and 4-ABA) as well as 2-phenylaminobenzoic acid (see 10, Fig. 2) [29,30]. These compounds displayed IC50 values in the nanomolar range, and 10 (R = H) blocked the growth in nude mice of a human lung carcinoma expressing oncogenic Ras [31]. 

Bhattacharjee, A., et al., "Classification of Human Lung Carcinomas by mRNA Expression Profiling Reveals Distinct Adenocarcinoma Subclasses," Proc. Natl. Acad. Sci. USA, 98, 13790-13795 (2001). 

A549 Human lung carcinoma epithelial-like... 

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Toxicology Irritating substance In vitro cytotoxicity on human lung Carcinoma Cell Line Hazard labeling Xn Harmful by inhalation, in contact with skin and if swallowed. May cause sensitization. 

ID50 15 pg/ml [5] (ID = inhibition dose) in vitro cytotoxicity on Human lung Carcinoma Cell Line... 

The polyhalogenated monoterpenes 57-59 from the Spanish sea hare Aplysia punctata show identical cytotoxic properties against P-388 mice lymphoma and HT-29 human colon carcinoma (ED50 2.5 pg/ml), A-549 human lung carcinoma and MEL-28 human melanoma cell lines (ED50 1.5 pg/ml) [57]. 

Secobatzelline A (83) from a sponge of the genus Batzella is active against P-388 (IC50 0.06 pg/ml) and human lung carcinoma A-549 cells (IC50 0.04 pg/ml) [73]. 

Kim YA, Lee WH, Choi TH, Rhee SH, Park KY, Choi YH. 2003a. Involvement of p21WAFl/CIPl, pRB, Bax and NF-kB in induction of growth arrest and apoptosis by resveratrol in human lung carcinoma A549 cells. Int J Oncol 23 1143-1149. 

Bhattacharjee A, Richards WG, Staunton J, et al. Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci USA 2001 98 13790-13795. 

Chien, P.-S., O.-T. Mak, and H.-J. Huang. 2006. Induction of COX-2 protein expression by vanadate in A549 human lung carcinoma cell line through EGF receptor and p38 MAPK-mediated pathway. Biochem. Biophys. Res. Commun. 339 562-568. 

The tartrate-based allylboronates were also used in the total synthesis of (+)-lasonolide A (61), which displays antitumor activity by inhibiting the invitro proliferation of A-549 human lung carcinoma cells26 (Scheme 3.1w). In the synthesis, the alcohol 62 was oxidized and then treated with the allylboronate f2 ,i )-41 to give the homoallylic alcohol 63 with 78% ee.Compound 63 was then... 

Corey and Roberts reported a total synthesis of the dysidiolide 46, a marine sponge metabolite with biological activities against A-549 human lung carcinoma and P388 murine leukemia cancer cell lines20 (Scheme 4.3p). The unwanted alcohol (47) was converted to the ketone 48 via Dess-Martin periodinane oxidation. The asymmetric reduction of 48 with the CBS catalyst 28b efficiently gave the alcohol 49, which was transformed into the dysidiolide 46 via photochemical oxidation. 

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