Human cervical carcinoma cells proliferation

Lancillotti F, Giandomenico V, Affabris E, Fiorucci G, Romeo G, Rossi G (1995) Interferon a-2b and retinoic acid combined treatment effects proliferation and gene expression of human cervical carcinoma cells. Cancer Res 55 3158-3164... 

Figure 3. Effect of psoralen-conjugated oligo(nucleoside phosphorothioate)s (PS-S-Oligo) on the proliferation of human cervical carcinoma cell, C4II. and SiHa. [A] C4II cell line. PS-P-As without UVA-irradiation (4-), PS-P-scr without UVA-irradiation (A ), PS-P-As with UVA-irradiation ( ), PS-P-scr with UVA-irradiation (A). [B] SiHa cell line. PS-P-As without UVA-irradiation ( ), PS-P-scr without UVA-irradiation (A), PS-P-As with UVA-irradiation ( ), PS-P-scr with UVA-irradiation (A). UVA-irradiation 365nm, I.lmJ/cm sec. Cell growth was evaluated by modified MTT assay.

The possible modes of action of 4HPR have been mostly investigated in already transformed tumor cells. 4HPR suppressed the proliferation of cell lines of different tumor types such as human breast carcinoma [24-27], prostate adenocarcinoma [28, 29], leukemias [30, 31], neuroblastoma [32, 33, 34], ovarian carcinoma [35, 36], cervical carcinoma [37, 38], head and neck squamous cell carcinoma [39], esophageal squamous carcinoma [40] and small-cell lung can-... 

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