Human lung carcinoma cell line

Courage C, Bradder SM, Jones T, Schultze-Mosgau MH, Gescher A (1997) Characterisation of novel human lung carcinoma cell lines selected for resistance to anti-neoplastic analogues of staurosporine. Int J Cancer 73 763-768... 

Shellard SA, Fichtinger-Schepman AMJ, Lazo JS, Hill BT. Evidence of differential cisplatin DNA adduct formation, removal and tolerance of DNA damage in three human lung carcinoma cell lines. Anti-Cancer Drugs 1993 4 491-500. 

Toxicology Irritating substance In vitro cytotoxicity on human lung Carcinoma Cell Line Hazard labeling Xn Harmful by inhalation, in contact with skin and if swallowed. May cause sensitization. 

ID50 15 pg/ml [5] (ID = inhibition dose) in vitro cytotoxicity on Human lung Carcinoma Cell Line... 

Chien, P.-S., O.-T. Mak, and H.-J. Huang. 2006. Induction of COX-2 protein expression by vanadate in A549 human lung carcinoma cell line through EGF receptor and p38 MAPK-mediated pathway. Biochem. Biophys. Res. Commun. 339 562-568. 

Both variolin B and its 5-deoxy derivative 19 (Scheme 6.1 Part 2) have shown promise in pharmacokinetic and in vivo studies. These compounds have been shown to have long terminal half-lives and low normal cell toxicity, however the 5-deoxy derivative demonstrated better Cmax, plasma clearance and terminal plasma half-life.318,319 Both are effective against human lung carcinoma cell lines in nude mice.104 The deoxy-variolin B showed growth inhibitory activity against human leukemic cell lines.105 A standardised method for liquid chromatography-mass spectrometry (LC-MS)/MS analysis of plasma has been developed to monitor the results of the in vivo studies.320... 

Human Lung Carcinoma Cell Line Human Cervical Carcinoma Human T-Cell Leukaemia Human Non Small Cell Lung Cancer Laryngeal Cancer Human Colon Cancer Human Colon Cancer... 

Cyathocaline exhibited moderate but selective activity in our yeast bioassay and also in a cytotoxicity assay against the A-549 human lung carcinoma cell line (Table 11). Three azafluorenone alkaloids have previously been tested for ( otoxic activity and were found to be inactive [53] but one has been reported to have anticandidal activity [54]. 

CYP26 expression in normal human tracheobronchial epithelial cells was compared with that in human lung carcinoma cell lines (Kim et al. 2000). CYP26 mRNA could be induced by the retinoic acid receptor-selective retinoid 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)-benzoic acid but not by the retinoid X receptor-selective retinoid SRI 1217 or the anti-activator-protein 1-selective retinoid SRI 1302. Retinoic acid receptor a-, P, and y-selective retinoids were able to induce CYP26 this induction was inhibited by the retinoic acid receptora-selective antagonist Ro41-5253. The induction of CYP26 correlated with increased biotransformation of retinoic acid into 18-hydroxy-, 4-OXO-, and 4-hydroxy-retinoic acid. 

In another study, the EO of the leaves of the Euphorbiaceae Croton flavens L. (yellow balsam) from Guadeloupe, a native plant from the Caribbean area, was analyzed by Sylvestre et al. (2006) and as main components viridiflorene (12.2%), germacrone (5.3%), (E )-Y-bisabolene (5.3%), and P-caryophyllene (4.9%) ascertained. The EO was found to be active against human lung carcinoma cell line A-549 and human colon adenocarcinoma cell line DLD-1. Three of the 47 components of the EO, namely a-cadinol, P-elemene, and a-humulene, showed also a cytotoxic activity against tumor cell lines. Yu et al. (2007) tested the EO of the rhizome of the Aristolochiaceae Aristolochia mollissima for its cytotoxicity on four human cancer cell lines (ACHN, Bel-7402, Hep G2, HeLa). The rhizome oil possessed a significantly greater cytotoxic effect on these cell lines than the oil from the aerial plant. 

In A549 cells (a human lung carcinoma cell line), B717 siRNA at a concentration of 100 nM almost completely suppressed the expression of Bcl-2 protein for 3 days (Fig. 2). Antisense DNA at ten times the concentration (1 pM) showed a weaker effect at all time points. Even though the antisense DNA was rendered nuclease-resistant by phosphorothioate modification, the duration of its activity was no longer... 

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