Cytotoxicity against human

Eupatin (69, R = H) and Eupatoretin (69, R = CH3), which are isolated from thistle perennials, show moderate cytotoxicity against human carcinoma of the nasopharynx (236). Baicaleia (70) salts exhibit antiallergic and antiinflammatory activity. 3,4,5-Trimethoxyphenoxyacetamides are hypotensives and diuretics and are useful for controlling arrhythmia duting anesthesia (237). 

Ishida T, et al. Targeted delivery and triggered release of liposomal doxorubicin enhances cytotoxicity against human B l5miphoma cells. Biochim Biophys Acta 2001 1515 144. 

OH r H CO2H HO H Marine fungi -Exserohilum rostratum Rostratin A - disuifide containing diketopiperazine with cytotoxicity against human coion carcinoma 232... 

Weak cytotoxicity against human cancer cells, KB and LoVo (colon adenocarcinoma), after treatment with microcarpalide 1, was also observed with the IC50 values of 50 Xg/mL and 90 Xg/mL, respectively. The ability of microcarpalide I (59) to disrupt microfilaments at subcytotoxic concentrations suggests its usefulness for future cell motility and metastasis studies, since other known microfilament disrupting agents such as cytochalasins are cytotoxic at biologically active concentrations. 

OS 157 Hyun, J. W., and H. S. Chung. Cyani-din and Malvidin from Oryza sativa cv. Heugjinjubyeo mediate cytotoxicity against human monocytic leukemia cells by arrest of G(2)/M phase and induction of apoptosis. J Agric Food Chem 2004 52(8) 2213-2217. 

Ito, H. et al., Polyphenols from Eriobotrya japonica and their cytotoxicity against human oral tumor cell lines, Chem. Pharm. Bull., 48, 687, 2000. 

Kazinol D (16) Cytotoxicity against human tumor cell lines [25]... 

Another compound, ansamitocin P3 (52), was isolated [36] from lichens of the family Thuidiaceae. However, it may be assumed that the lichens do not synthesize this compound but that it is rather a product of streptomycetes living on surface of these lichens. Ansamitocin P3 exhibits an excellent cytotoxicity against human tumors, leukemia and carcinoma in cell cultures. 

Encelin from Montanoa speciosa is inhibitory to growth and development of fungal cells of Mucor rouxii. Other cytotoxic sesquiterpene lactones from Montanoa tomentosa ssp. microcephala have been reported.45,46 A number of kaurane diterpenes and e/tf-kauranoids have been reported that are potentially useful because of their cytotoxicity against human tumor cells, anti-HIV activity, and trypanosomicidal activity.47 56 New structures are frequently discovered, and probably we will learn new effects in humans and animals in the future.57,58 Paradoxically, these plant natural products probably have specific and important effects in the plants, but we are still ignorant of these roles. 

In the present study, we describe the effects produced by 3-formyl-chromones substituted at the 6-position. We evaluated their cytotoxicity against human tumor cell fines and normal cells, and also investigated the structurally related coumarine (2H- l-benzopyran-2-one) derivatives [24]. 

Heterocycles such as 4-trifluoromethylimidazole, phenoxazine, 3-formyl-chromone, coumarin derivatives, and vitamin K2 derivatives were investigated for their cytotoxicity against human normal and tumor cells. These compounds induced moderate tumor-specific cytotoxicity. VitaminK2 derivatives and prenylalcohols displayed disappointingly low tumor-specific cytotoxicity, although they have been reported to induce apoptosis-inducing activity. Human oral squamous cell carcinoma cell lines showed considerable variation in drug sensitivity. The type of cell death induced depended both on which types of cells and which inducers were used. 

They are flavonoids without the C-ring and are not frequently isolated from plants, possibly due to their instability. So, most of the chalcones presented in this review are synthetics [80, 79]. This kind of flavonoids, generally, are rather cytotoxic against human cancer cells. Thus, xantohumol, a prenylated chalcone from hops, inhibited the A-2780 cell line at a IC50 of 0.5 pM [56] and two synthetic chalcones inhibited the HeLa cell line at IC50 of 0.0038 pg/mL [80]. 

Four new cytotoxic disulfides, rostratins A-D 57-60, were isolated from the broth of the marine-derived fungus Exserohilum rostratum (Drechsler), a fungal strain found associated with a marine cyanobacterial mat. These compounds showed in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 values of 8.5, 1.9, 0.76, and 16.5 pg mL, respectively. 

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