Expression patterns

M Schena, D Shalon, RW Davis, PO Brown. Quantitative monitoring of gene expression patterns with a complementary DNA microaiTay. Science 270 467-470, 1995. 

D Shalon, SJ Smith, PO Brown. A DNA microairay system for analyzing complex DNA samples using two-color fluorescent probe hybridization. Genome Res 6 639-645, 1996. MB Eisen, PT Spellman, PO Brown, D Botstem. Cluster analysis and display of genomewide expression patterns. Proc Natl Acad Sci USA 95 14863-14868, 1998. 

C1C-3, -4 and -5 form the second branch of the CLC gene family. These proteins are 80% identical, and with the exception of C1C-5, which is most highly expressed in kidney and intestine, show a broad expression pattern. C1C-3 to C1C-5 reside in intracellular membranes of the endocytotic pathway [4]. Disruption of C1C-5 leads to a defect in endocytosis in mouse... 

Fak (focal adhesion kinase) is expressed in most tissues and is evolutionary conserved across species. It is activated by integrin clustering and by stimulation of several G protein-coupled recqrtors and RTKs. Fak is associated with focal adhesions and regulates cell spreading and migration. The kinase is essential for embryonic development since the homozygote Fak knockout is embryonic lethal. Pyk2 (proline-rich tyrosine kinase 2), the second member of the Fak kinase family has a more restricted expression pattern (primarily neuronal and hematopoietic cells) and does not localize to focal adhesions. 

Lai CL, Chao YC, Chen YC, et al No sex and age influence on the expression pattern and activities of human gastric alcohol and aldehyde dehydrogenases. Alcohol Clin Exp Res 24 1625—1632, 2000... 

Profiling of wheat class III peroxidases genes derived from powdery mildew-attacked epidermis reveals distinct sequence-associated expression patterns / / Molecular Plant-Microbe Interactions. V. 18. P. 730-741. 

The NMDA receptor has a heteromeric structure composed of two subunit types NRl and NR2, the latter having four subunits (NR2A-NR2D) (Fig. 10.2). Molecular genetic techniques have demonstrated that native NMDA receptors are likely to be composed of a combination of the NRl subunit (which can exist in eight different splice variants) and one or more of the four NR2 subunits which are the main determinants of functional diversity among the NMDA receptors (see Chapter 3 for further details). It has been shown that there are distinct developmental and spatial expression patterns of NMDA receptor NRl subunit splice variants and NR2 receptor subunits in the CNS. 

It is accepted that oxidation of LDL is a key event in endothelial injury and dysfunction. Oxidised LDL (oxLDL) may directly injure the endothelium and trigger the expression of migration and adhesion molecules. Monocytes and lymphocytes interact with oxLDL and the phagocytosis which follows leads to the formation of foam cells, which in turn are associated with the alteration of the expression pattern of growth regulatory molecules, cytokines and pro-inflammatory signals. The proposed role of oxLDL in atherogenesis, based on studies in vitro, is shown in Fig. 2.1. 

Magert H., Hadrys T., Cieslak A., Groger A., et al. (1995). cDNA sequence, and expression pattern of the putative pheromone carrier aphrodisin. Proc Natl Acad Sci 92, 2091-2095. 

Matsuoka M., Yokosuka M., Mori Y. and Ichikawa M. (1999). Specific expression pattern of Fos in the accessory olfactory bulb of male mice after exposure to soiled bedding of females. J Neurosci Res 35, 189-195. 

Saito S. and Taniguchi K. (2000). Expression patterns of glyco-conjugates in the three distinctive olfactory pathways of the clawed frog, Xenopus laevis. J Vet Med Sci 62, 153-159. 

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