Gas chromatograph/mass spectrometer system

Mass spectral studies have also been used more extensively. Soviet investigators at Tashkent in their mass spectral analyses of the Aconitum and Delphinium alkaloids have provided a mass spectral data base of great utility in the structure elucidation of new alkaloids with the lycoctonine skeleton. A study employing trimethylsilyl derivatives in a gas chromatograph-mass spectrometer system has also been reported. A brief review of mass spectral studies on diterpene alkaloids has appeared. ... 

An Assay for Diphenoxylic Acid in Urine Using an Automated Gas Chromatograph Mass Spectrometer system Quant. Mass Spectrom. Life Sci. 2 287-293 (1978) CA 91 13346w... 

FIGURE 7.1 Schematic diagram of a typical gas chromatograph/mass spectrometer system. Gaseous analytes eluting from the chromatograph are directed into the spectrometer ion source where they are ionized. The ions produced are separated according to their miz values and detected. 

The filtrate was lyophylized and the solid residue silylated with BSTFA+1% TMCS at 60 C for 10 min. The silylated sample was analyzed in a combined gas chromatograph-mass spectrometer system (Finnigan, Model 3300) operated under the following conditions Gas chromatographic column 3% OV-17 or 3% SE-30, 1 m long, 2 mm ID injection temperature is 270 C, temperature programming is from 175 to 240 C at 8°/min, The effluent entered the mass spectrometer via a heated 240 C interface (without molecular separator). 

Gas chromatography-mass spectrometry. A Finnigan 3300 gas chromatograph-mass spectrometer system operated on line with a Finnigan 6000 data system was used for all analyses. Thirty m x 0.3 ram support-coated open tubular (SCOT) gas chromatographic glass columns with OV-1 as the liquid phase were used for these studies. 

Data acquisition in combined gas chromatograph-mass spectrometer systems (low resolution) is usually performed either in the... 

R.A. Heppner. Elemental detection with a microwave-induced plasma/gas chromatograph-mass spectrometer system. Anal. Chem., 55(13), 2170 (1983). 

The high temperatures in the MHD combustion system mean that no complex organic compounds should be present in the combustion products. Gas chromatograph/mass spectrometer analysis of radiant furnace slag and ESP/baghouse composite, down to the part per biUion level, confirms this behef (53). With respect to inorganic priority pollutants, except for mercury, concentrations in MHD-derived fly-ash are expected to be lower than from conventional coal-fired plants. More complete discussion of this topic can be found in References 53 and 63. 

GCMS-QP 2000 gas chromatograph mass spectrometer, GCMS-Q 1000 and GC-QP 1000A gas chromatograph mass spectrometer Mispack 200 GCMS QP series MS data system... 

Subsequently, modified thermal decomposition systems were developed by the University of Dayton to investigate the destruction of complex hazardous waste mixtures ]). These systems utilized various combinations of gas chromatographs/mass spectrometers/computers which were incorporated into the vaporization and decomposition process. 

Analysis of the Mixture of Organic Compounds from the Soil. The crude fractions were analyzed using a LKB-2091 capillary gas chromatograph/mass spectrometer/data analysis system (CGC/MS/DA). The capillary column used was a J W DB-1, 60 m x 0.32 mm, connected directly to Ae ion source of the mass spectrometer. Up to 1.0 tfL of a solution of the sample in an appropriate solvent was injected directly onto the column at 40 °C, whereupon the column temperature was immediately raised to 100 for 4 min, and programmed to 310 °C at a rate of 10°/min. and held there for 30 min. 

The reaction system consisted of a flow stainless steel microreactor operated at 5 MPa and 523-623 K. Hydrogen and carbon monoxide were supplied to the reactor through mass flow controllers (Brooks). Products were sampled through heated lines into an on-line gas chromatograph equipped with TCD and FID detectors, with a Porapak Q + R column for Ci products and a Tenax column for hydrocarbons (C,-C13) or alcohols (Cj-Cfi), respectively. Reaction products were identified with a gas chromatograph-mass spectrometer (Hewlett-Packard Model 5971), using a 60 m DB-1 capillary column (J W Scientific). 

Sastry and Waller (89,160) analyzed a deuterated trimethylsilyl derivative of ajaconine on a gas chromatograph-mass spectrometer (GC-MS) system. They found that the crystalline sample earlier identified as pure ajaconine was a mixture of five compounds. Peak 1 with retention time (Rt) of 12.7 min had a molecular ion of 477. Peaks 2 (/ , = 17.3 min), 3 (Rx = 21.0 min), and 4 (Rx = 25.5 min), all with a molecular ion of 521 (503 for the non-deuterated TMS derivatives), accounted for the di-TMS derivatives of... 

To analyse the solvent extracts a lOpL aliquot of the concentrated extract was injected into a Finnigan 4000 gas chromatograph-mass spectrometer coupled to a 6110 data system. A 3% OV-17 provided the best separation of the detectable PAHs. Quantitative estimations of the detectable O-PAHs in Ottawa drinking water were obtained by comparison of the areas of the two characteristic ion peaks (Tablesl6.2 and 16.3) in the mass chromatograms of the reference standard and the field sample, respectively. No corrections were made for incomplete recovery. Of the 50 PAHs in the standard used by Benoit et al. [119], 38 are detected in at least one of the drinking water samples tested. 

A gas chromatography-mass spectrometer consists of gas chromatograph, mass spectrometer and computer-based data acquisition systems. Since success... 

H9. Hawk, R. E., and Jennings, R. W., Construction of a leak-inlet system for the LKB 9000 gas chromatograph-mass spectrometer. Appl. Spectrosc. 24, 543-544 (1970). 

Gas Chromatography-Mass Spectrometry. A Finnigan MAT 4500 series quadrupole gas chromatograph/mass spectrometer/data system equipped with the same capillary column and using the same temperature program described in the previous section was employed. Helium was used as the carrier gas at an average linear velocity of 47.7 cm/sec (30°C). Injector temperature was 220°C, and the ion source temperature was 180°C. The outlet end of the fused silica column was inserted directly into the ion source block, which was maintained at approximately 180°C. 

GC-MS Analysis and Identification. A portion of the acidic fractions were quantitatively converted to methyl esters using a BF3-methanol reagent. The procedure used was that of Metcalfe and Schmitz (8). The esterified acidic fractions were analyzed using a coupled gas chromatograph-mass spectrometer (GC-MS) system consisting of a Varian Moduline 2700 gas chromatograph equipped with a flame ionization detector interfaced by a jet separator to a Du Pont Instruments Model 21-490 mass spectrometer. A 10 ft x 1/8 in o d stainless steel column packed with 10% stabilized DEGS on 80/ 100 mesh Chromosorb W AW DWCS was used. The He flow rate was 30 ml/min. The column temperature was held 5 minutes at 30°C, then... 

Besides the universal detector systems, for example electron capture, flame ionisation and thermal conductivity usually coupled with gas chromatographic columns, various other detectors are now being used to provide specific information. For example, the gas chromatograph/mass spectrometer couple has been used for structure elucidation of the separated fractions. The mechanics of this hybrid technique have been described by Message (1984). Other techniques used to detect the metal and/or metalloid constituents include inductively coupled plasma spectrometry and atomic absorption spectrometry. Ebdon et al. (1986) have reviewed this mode of application. The type and mode of combination of the detectors depend on the ingenuity of the investigator. Krull and Driscoll (1984) have reviewed the use of multiple detectors in gas chromatography. 

Because of the dramatic expansion in environmental organic analysis and the development of commercially available gas chromatograph-mass spectrometer (GC-MS) systems, there have been niunerous organic contaminant fingerprints that have been described and identified [2-4, 7-24]. Identities of individual compounds or compositional fingerprints can be determined by highly sophisticated and advanced instruments [23, 25-40], and are used to provide information about the type [22,23,34,41-44], amount [41,45-48], and source confirmation [1-4,49] of these contaminants. The following is a siunmary. 

Polymeric materials then, whether natural (such as cellulose, resins, and proteins) or synthetic (such as polyolefins, nylons, and acrylics), behave in reproducible ways when exposed to pyrolysis temperatures. This permits the use of pyrolysis as a sample preparation technique to allow the analysis of complex materials using routine laboratory instruments. Pyrolytic devices may now be interfaced easily to gas chromatographs, mass spectrometers, and FT-IR spectrometers, extending their use to solid, opaque, and multicomponent materials. Laboratories have long made use of pyrolysis for the analysis of paint flakes, textile fibers, and natural and synthetic rubber and adhesives. The list of applications has been expanded to include documents, artwork, biological materials, antiquities, and other complex systems that may be analyzed with or without the separation of various layers and components involved. 

The experimental conditions and the injection procedure were essentially the same as those in the irritation studies. Blood samples were collected from the ear vein at appropriate time intervals following treatment and centrifuged to obtain the serum for analysis. The extraction procedure of CPZ in the serum was performed according to the modified method of Mckay et al. (8). The quantification of CPZ was carried out on a gas chromatograph-mass spectrometer-computer system. The instrument was used in the selected ion monitoring mode. 

Identification of the Drug Darvon and Its Metabolites in the Urine of a Comatose Patient Using a Gas Chromatograph-Mass Spectrometer-Computer System... 

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