Evaluation potential impact

Corrosion tests are performed to evaluate potential impacts on steel or concrete structures due to chemical attack. Tests to evaluate corrosion potential include resistivity, pH, sulfate content, and chloride content. 

Site Selection Factors that must be considered in evaluating potential solid-waste-disposal sites are summarized in Table 25-71. Final selection of a disposal site usually is based on the results of a preliminary site survey, results of engineering design and cost studies, and an environmental-impact assessment. 

In many cases, it is not readily apparent how the potential impacts from different hazards can be translated into some common scale or measure. For example, how do you compare long term environmental damage and health risks from use of CFG refrigerants to the immediate risk of fatality from the fire, explosion, and toxicity hazards associated with many alternative refrigerants This question does not have a right answer. It is not really a scientific question, but instead it is a question of values. Individuals, companies, and society must determine how to value different kinds of risks relative to each other, and base decisions on this evaluation. 

Ideally, one would prefer to compare anodic and cathodic potential limits instead of the overall ionic liquid electrochemical window, because difference sets of anodic and cathodic limits can give rise to the same value of electrochemical window (see Figure 3.6-1). However, the lack of a standard reference electrode system within and between ionic liquid systems precludes this possibility. Gonsequently, significant care must be taken when evaluating the impact of changes in the cation or anion on the overall ionic liquid electrochemical window. 

In the near future new drugs for the treatment of Alzheimer s disease are expected to be licensed, and it would be extremely valuable to be able to compare them in a clear and well-defined framework. In addition, if economic evaluation is to inform health and social care providers and policy-makers about the potential impact of new interventions in practice, estimation of the value for money of these new interventions requires consideration of (a) the perceived and objective risks and benefits of care (b) attitudes of people with... 

For screening purposes, however, the analysis has shown that a building of low blast resistance and high episodic occupancy, and that is potentially impacted by three different process units may present an undue aggregate risk and should be evaluated further. In retrospect, this conclusion should have been obvious without the need to resort to the risk-screening analysis. 

Johnson, B.T. 1986. Potential impact of selected agricultural contaminants on a northern prairie wetland a microcosm evaluation. Environ. Toxicol. Chem. 5 473-485. 

Developed environmental accounting and evaluation methods based on relevant parameters indicating potential impacts on the environment make it possible to describe and monitor processes, states and tendencies of the agricultural production systems at various levels (Hiilsbergen 2003 Piorr 2003 Delbaere and Serradilla 2004 Zinck et al. 2004 Bergstrom et al. 2005 Meyer-Aurich 2005 Payraudeau and van der Werf 2005 Bockstaller et al. 2007). 

The potential impacts of organic leachates from complex mixtures on surface and ground waters appear to be of environmental concern, thus the testing methodology provides a systematic approach for such evaluations. 

The ICH S7A guidance states that "supplemental" studies are meant to evaluate potential adverse pharmacodynamic effects on organ systems functions that are not acutely essential for the maintenance of human life and not addressed by the "core battery" or repeated dose toxicity studies when there is a cause for concern.25 Examples of physiological functions that fall into that category include, but are not limited to, the renal/urinary, immune, GI, endocrine and autonomic nervous systems. This section focuses on the renal and GI systems based on their potential impact on the clinical development program. 

In terms of anthropogenic stress (the effect of human activity on other organisms), there is a need for the identification and evaluation of the potential impacts of proposed projects, plans, programs, policies, or legislative actions on the physical-chemical, biological, culmral, and socioeconomic components of the... 

Crowley and Martini [48] reported on several studies evaluating the impact of unit process operations on hydrates. AU showed some level of dehydration liberating freed crystalline water to participate in moisture-mediated reactions. The authors speculated that such energetic processing conditions are likely to have a similar affect on hydrated excipients with a potential deleterious effect on moismre-sensitive APIs. They commented that classical excipient compatibility studies were ill-equipped to predict such moismre-mediated interactions and that compression, attrition and other energy-intensive unit operations were rarely mentioned as requiring investigations. 

Clewell et al. (2002b) have reviewed and evaluated the potential impact of age-specific pharmacokinetic differences on tissue dosimetry. A large number of age-specific quantitative differences in pharmacokinetic parameters were identified. The majority of these differences were identified between neonates/children and adults, with fewer differences being identified between young adults and the elderly. 

Clewell, H.J., J. Teeguarden, T. McDonald, et al. 2002b. Review and evaluation of the potential impact of age-and gender-specihc pharmacokinetic differences on tissue dosimetry. Crit. Rev. Toxicol. 32 329-389. 

Thus, the potential Impact of an allelochemical on plant growth should be evaluated with regard to both the presence of associated allelopathic compounds and the influence of other chemical and physical conditions in the environment. Certainly allelochemical action is not an isolated event, and from the standpoint of plant functions, the controversy between competitive and allelochemical Interference loses some of its significance. Allelochemical action needs to be regarded with a holistic view where one stress may reinforce, or magnify, another. From this perspective, inhibition of plant growth is not so much a matter of which factor is most detrimental instead it is determined by the interaction of multiple stresses. 

Concerns about chemicals in the environment have focused major attention on the possible consequence for humans, animals, and whole ecosystems. However, we still lack back basic knowledge and procedures for evaluating the potential impacts of chemicals, compound mixtures, or artificial concentrations of natural substances that have an adverse effect on human health and the environment. Such knowledge will be essential for developing products with adequate safeguards against unwanted side effects. 

Cross-validation of the DFA model is conducted by casewise deletion, reestimation of functions, and classification. In other words, for each observation in the data set, that observation is omitted and the discriminant functions are re-estimated using the full data set minus that observation. Then that observation is classified based on the re-estimated functions. The accuracy of the cross-validation can be used to evaluate the reliability of the DFA and the potential impact of group outliers. In essence, the cross-validation process is the same process used to determine provenance of an unsourced archaeological sample where the discriminant functions are developed independently of the sample and then used to determine its most likely source. 

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