Mediated interactions

Structural studies of a repressor-DNA complex have shown that helices 4 and 5 form a helix-turn-helix motif and that side chains from the recognition helix 5 form water-mediated interactions with bases in the major groove. 

Baumgartner and coworkers [145,146] study lipid-protein interactions in lipid bilayers. The lipids are modeled as chains of hard spheres with heads tethered to two virtual surfaces, representing the two sides of the bilayer. Within this model, Baumgartner [145] has investigated the influence of membrane curvature on the conformations of a long embedded chain (a protein ). He predicts that the protein spontaneously localizes on the inner side of the membrane, due to the larger fluctuations of lipid density there. Sintes and Baumgartner [146] have calculated the lipid-mediated interactions between cylindrical inclusions ( proteins ). Apart from the... 

PTKs can be subdivided into two large families, receptor tyrosine kinases (RTKs) and non-RTKs. The human genome encodes for a total of 90 tyrosine kinases of which 32 are nonreceptor PTKs that can be placed in 10 subfamilies (Fig. 1). All nonreceptor PTKs share a common kinase domain and usually contain several additional domains that mediate interactions with protein-binding partners, membrane lipids, or DNA (Table 1). These interactions may affect cellular localization and the activation status of the kinase or attract substrate proteins for phosphorylation reactions. 

Shpetner, H.S. Vallee, R.B. (1989). Identification of dyamin, a novel mechanochemical enzyme that mediates interactions between microtubules. Cell 59,421-432. 

Harrison JK, Barber CM, Lynch KR (1994) cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors. Neurosci Lett 169 85-89 Harrison JK, Jiang Y, Chen S et al (1998) Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Proc Natl Acad Sci USA 95 10896-10901... 

Haberland, M.E., Olch, C.L. and Fogelman, A.M. (1984). Role of lysines in mediating interaction of modifed low density lipoproteins with the scavenger receptor of human monocyte macrophages. J. Biol. Chem. 259, 11305-11311. 

Initial studies examining the function of siderophores in the rhizosphere have focused on practical problems related to agricultural biotechnology. Early research suggested the involvement of siderophores in plant disease suppression by certain root-colonizing pseudomonads (2). Since then, it has become apparent that siderophore-mediated interactions are only part of the story of how microor-... 

Troponins T or I Proteins found predominantly in cardiac muscle that regulate calcium-mediated interaction of actin and myosin troponins I and T are released into the blood from myocytes at the time of myocardial cell necrosis after infarction. These biochemical markers become elevated and are used in the diagnosis of myocardial infarction. 

Tetratrophic interactions between a host plant, a phytophagous pest (primary host), a hymenopteran parasitoid or symbiont (secondary host) and a hymenopteran hyperparasitoid (which parasitizes the secondary host) are of considerable importance, because hyperparasitism can significantly reduce populations of economically beneficial parasitoids [11]. Hyperparasitoids use host-marking (=spacing) pheromones, sex pheromones [12], and host-detection cues [42], but they also show additional chemically mediated interactions with the other partners. These include detection of the primary host s secretions by the hyperparasitoid [43], detection of plant volatiles by the hyperparasitoid [44], and detection of the hyperparasitoid s secretions by the primary host [45] or by the secondary host. The latter causes the secondary host to avoid locations where the hyperparasitoid is foraging [46]. 

Paul That s an interesting question. I have never done it in a non-cumulative fashion. My assumption was that it was always Ca2+ sensitized. The Ca2+ force curve seemed to be steeper than with the KC1. I was assuming that any level of receptor-mediated interaction would lead to sensitization. 

The occurrence of the substrate-mediated interaction between adatoms was first predicted in the seminal work by Koutecky (1958), using the resolvent technique, and was later clarified in a review by Grimley (1960), who added significantly to the theory by showing that the interaction energy is long-... 

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