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Structure drugs

The low structural requirements for local anesthetic activity do not maintain in all classes of drugs. Structural requirements for biologic activity in fact follow a full continuum from those cases in which addition of a single carbon atom serves to abolish activity to the case of the local anesthetics that tolerate quite drastic alterations. [Pg.20]

Shulgin AT Hallucinogens, in Burger s Medicinal Chemistry, 4th Edition, Part 3. Edited by Wolff ME. New York, Wiley, 1981, pp 1109-1137 Shulgin AT Psychotomimetic drugs structure-activity relationships, in Handbook of Psychopharmacology, Vol 11. Edited by Iversen LD, Iversen SD, Snyder SH. New York, Plenum, 1978, pp 243-336... [Pg.241]

While there is a vast range of different drug structures, there are only a relatively small number of chemical reactions, some of which are shown below in Table 5.13 (p. 199), involved in the production of metabolites. Based on the structure of the drug, it is therefore possible to predict the most likely metabolites. Use may then be made of reconstructed ion chromatograms (RlCs) of mlz values corresponding to the predicted molecular weights of these metabolites to locate them within the LC-MS data obtained. [Pg.250]

In the search for new anti-inflammatory drugs structurally derived from indomethacine [147], Pravadoline showed psychotropic side effects in clinical trials. It became apparent that these effects are mediated through the cannabinoid receptor. Optimization of the structure Anally led to WIN-55,212-2 (8.6), which has a higher affinity to the CBl receptor than THC [148]... [Pg.34]

Shulgin, A.T. Psychotomimetic drugs Structure-activity relationships. In Iversen, L.L. Iversen, S.D. and Snyder, S.H., eds. Handbook of Psychopharmacology. Vol. 11. New York Plenum, 1978. pp. 243-333. Shulgin, A.T., and Carter, MF. Centrally active phenethylamines. [Pg.67]

Phase I metabolism The introduction of a polar group, e.g. an hydroxyl group, into a parent drug structure prior to its elimination from the body. [Pg.253]

It was postulated that the aqueous pores are available to all molecular species, both ionic and non-ionic, while the lipoidal pathway is accessible only to un-ionised species. In addition, Ho and co-workers introduced the concept of the aqueous boundary layer (ABL) [9, 10], The ABL is considered a stagnant water layer adjacent to the apical membrane surface that is created by incomplete mixing of luminal contents near the intestinal cell surface. The influence of drug structure on permeability in these domains will be different for example ABL permeability (Paq) is inversely related to solute size, whereas membrane permeability (Pm) is dependent on both size and charge. Using this model, the apparent permeability coefficient (Papp) through the biomembrane may therefore be expressed as a function of the resistance of the ABL and... [Pg.37]

Table 16.5 General structure of a sulfa drug, structure of five sulfa drugs containing six-mem-bered heterocyclic R substituents, and measured pK values pK values were calculated using a spectrophotometric titration. Errors represent the 95% confidence levels and both the values and the associated errors were obtained from fits of the data using Scientist for Windows. Reprinted with permission from Boreen AL, Arnold WA, McNeil K (2005) Triplet-sensitized photodegradation of sulfa drugs containing six-membered heterocyclic groups identification of an S02 extrusion photoproduct. Environ Sci Technol 39 3630-3638. Copyright 2005 American Chemical Society... Table 16.5 General structure of a sulfa drug, structure of five sulfa drugs containing six-mem-bered heterocyclic R substituents, and measured pK values pK values were calculated using a spectrophotometric titration. Errors represent the 95% confidence levels and both the values and the associated errors were obtained from fits of the data using Scientist for Windows. Reprinted with permission from Boreen AL, Arnold WA, McNeil K (2005) Triplet-sensitized photodegradation of sulfa drugs containing six-membered heterocyclic groups identification of an S02 extrusion photoproduct. Environ Sci Technol 39 3630-3638. Copyright 2005 American Chemical Society...
A group of drugs structurally related to amphetamines that suppress appetite and which are used in treatment of obesity are called analeptics. [Pg.123]

DRUG MOLECULES STRUCTURE AND PROPERTIES 1.2.1 Role and Structure of Water Influence on Drug Structure... [Pg.25]

No matter which system might eventually prove to be the best, the use of a chemical assignment of drug structure to the active components allows some form of clinical challenge to the native use in the field. DMT and 5-MeO-DMT are the mainstay chemicals in most snuffs,... [Pg.59]


See other pages where Structure drugs is mentioned: [Pg.729]    [Pg.151]    [Pg.166]    [Pg.249]    [Pg.470]    [Pg.498]    [Pg.502]    [Pg.27]    [Pg.8]    [Pg.156]    [Pg.77]    [Pg.19]    [Pg.182]    [Pg.76]    [Pg.149]    [Pg.149]    [Pg.192]    [Pg.143]    [Pg.146]    [Pg.165]    [Pg.204]    [Pg.116]    [Pg.61]    [Pg.271]    [Pg.8]    [Pg.26]    [Pg.140]    [Pg.31]    [Pg.17]    [Pg.18]    [Pg.97]    [Pg.489]   
See also in sourсe #XX -- [ Pg.4 , Pg.5 , Pg.6 , Pg.7 , Pg.18 ]




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Aminocarbafuranoses in structure-based drug discover

Anti-inflammatory drugs structure

Antiarrhythmic drugs structure

Antibodies, large molecule drug structure

Antidepressant drugs structure-activity

Antimalarial drugs structure

Antiseizure drugs structure

Antisense drugs structure

Application of NMR to structure confirmation in some drug molecules

B.A. Baldo and N.H. Pham, Drug Allergy: Clinical Aspects, Diagnosis, Mechanisms, Structure-Activity

Cannabinoid drugs structure-activity relationships

Cholesterol-lowering drugs, structure

Dendrimer structures, polymeric drug

Dendrimer structures, polymeric drug delivery systems

Dorzolamide A Success Story of Structure-Based Drug Design

Drug bioanalysis structures

Drug candidates structures

Drug degradants rapid structural identification

Drug delivery and marine structures

Drug delivery supramolecular structures

Drug delivery systems structure and properties

Drug delivery vehicle structure

Drug design lead’ structure selection

Drug design protein structure-based methods

Drug design quantitative structure-activity

Drug design quantitative structure-activity relationships

Drug design receptor structure

Drug design structure - activity relationships

Drug design structure, ligand-based models

Drug design structure-assisted lead optimization

Drug design structure-based methods

Drug design, structural alerts

Drug design/discovery structure-based

Drug development chemical structures

Drug development structural genomics

Drug development structure-based

Drug industry, structure

Drug metabolism studies structural elucidation

Drug metabolites structure determination

Drug molecules structure

Drug properties structure-based design

Drug research structure modification

Drug resistance structural modifications

Drug structural interpretation

Drug structure betamethasone

Drug structure chemical

Drug structure paracetamol

Drug structure-based

Drug structure-based strategy

Drugs Structural-activity relationships)

Drugs inclusion structures

Drugs quantitative structure-activity relationship

Drugs structure-activity relationship , (

Drugs, electronic structure

Examples of Structure-Based Drug Design

Gold drugs crystal structures

H-bonding Parameterization in Quantitative Structure-Activity Relationships and Drug Design

Heparin, anticoagulant drug structure

Lead compound production structure-based drug design

Lead compounds structure-based drug design

Ligand- and Structure-based Drug Design

Molecular structure, drugs

Nonsteroidal anti-inflammatory drugs structures

Nuclear magnetic resonance drug structure determination

PAMPA 50 Model Lipid Systems Demonstrated with 32 Structurally Unrelated Drug Molecules

Pharmacogenetic Effects of Palliative Drugs due to Structural Target Diversity

Plants as a Source of Lead Structures and Drugs

Platinum anticancer drugs structure—activity relationships

Quantitative structure-activity relationships drug design optimization

Quantitative structure-activity relationships selective drug design

Rational drug design lead structure compounds

Representing Chemical Structures in Databases for Drug Design

Rules of Thumb for Structure-Based Drug Design

Sila drugs, structure

Solubility and drug structure

Spectrophotometry, drug structure

Steps in Structure-Based Drug Design

Structural Interpretation of Drug Binding

Structural alkaloid drug metabolites

Structural analogs antipsychotic drugs

Structural biologists drug discovery

Structural biology drug discovery

Structurally specific drugs

Structure and Functions of Some Common Drugs

Structure based drug design drugs

Structure based drug design introduction

Structure based drug design process

Structure determination of drug

Structure drug design

Structure-activity relationship anti-cancer drugs

Structure-activity relationship drug discovery

Structure-activity relationships drug quality

Structure-activity relationships drug-receptor interactions

Structure-activity relationships small molecule drug

Structure-aided drug design

Structure-based drug design

Structure-based drug design (SBDD

Structure-based drug design and combinatorial chemistry

Structure-based drug design approaches

Structure-based drug design characterization

Structure-based drug design examples

Structure-based drug design future targets

Structure-based drug design iterative cycles

Structure-based drug design novel lead structures

Structure-based drug design proteases

Structure-based drug design protein crystallography

Structure-based drug design three-dimensional

Structure-function drug design

Structured Biodegradable Polymers for Drug Delivery

Structures and Classification of Cephalosporin Drugs

Structures of drugs

Synthetic drugs structures

The ABC Transporters Structural Insights into Drug Transport

Three-dimensional quantitative structure-activity relationship drug design

Virtual screening structure-based drug design/discovery

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