Solubility and drug structure

The importance of water solubility in drug action means that one of the medicinal chemist s development targets for a new drug is to develop analogues that have the required degree of water solubility. 

The water solubility of a lead compound can be improved by three general methods salt formation (see section 3.5), by incorporating water solubilizing groups into its structure (see section 3.6), especially those that can hydrogen 

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