Structure-based drug design and combinatorial chemistry

Murray CW, Clark DE, Auton TR, Firth MA, Li J, Sykes RA, Waszkowycz B, Westhead DR, Young SC. PRO SELECT combining structure-based drug design and combinatorial chemistry for rapid lead discovery. J Comput Aided Mol Des 1997 11 193-207. 

Salemme FR, Spurlino J, Bone R. Serendipity meets precision the integration of structure-based drug design and combinatorial chemistry for efficient drug discovery. Structure 1997 5 319-324. 

Westhead, and S. C. Young,/. Comput.-Aided Mol. Des., 11, 193 (1997). PRO SELECT Combining Structure-Based Drug Design and Combinatorial Chemistry for Rapid Lead Discovery. 1. Technology. 

C. W. Murray, D. E. Clark, T. R. Auton, M. A. Firth, J. Li, R. A. Sykes, B. Waszkowycz, D. R. Westhead, and S. C. Young PRO SELECT Combining structure-based drug design and combinatorial chemistry for rapid lead discovery. 

F. R. Salemme, J. Spurlino, and R. Bone, Structure, S, 319 (1997). Serendipity Meets Precision The Integration of Structure-Based Drug Design and Combinatorial Chemistry for Efficient Drug Discovery. 

Combinatorial chemistry. Adding 3D information to real and virtual chemical libraries will enhance library selection and refinement. The results of combinatorial experiments which utilize 3D information should be more biologically applicable, and lead to structure-based drug design and 3D QSAR experiments for lead optimization. ... 

Antel, j. Integration of combinatorial chemistry and structure-based drug design. Curr. Opin. Drug Disc. Dev. 1999,... 

Structure-Based Drug Design Combinatorial Chemistry and Molecular Modeling. 

Li, J., Murray, C.W., Waszkowycz, B. and Young, S.C. Targeted Molecular diversity in drug discovery integration of structure-based design and combinatorial chemistry. Drug Discovery Today, 1998,3,105-112. 

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