Structural requirements for

Polakis, P, McCormick, E Structural requirements for the interaction of p21 with GAP, exchange factors, and its biological effector target. /. Biol. Chem. 268 9157-9160, 1993. 

However, this does not explain the structural requirements for the oxygen function vicinal to the nitrite ester a-ketones, ketals and hydroxyls are cleaved, but a-acetoxyls are not. 

The low structural requirements for local anesthetic activity do not maintain in all classes of drugs. Structural requirements for biologic activity in fact follow a full continuum from those cases in which addition of a single carbon atom serves to abolish activity to the case of the local anesthetics that tolerate quite drastic alterations. 

It was therefore of some interest to so modify the molecule as to maximize this particular activity at the expense of the side effects. In much the same vein as the work on cocaine, the structural requirements for the desired activity had at one time been whittled down to embrace in essence an a-substituted phenylacetic acid ester of ethanolamine (S3). 

The apparently loose structural requirements for antihista-iiiinic agents have already been alluded to. Thus, active compounds. ire obtained almost regardless of the nature of the atom that connects the side chain with the benzhydryl moiety. In fact, a methylene group, too, can also serve as the bridging group. Reaction of the aminoester, 95 (obtained by Michael addition of... 

The structural requirements for such activity are not very confining, as can be seen in part by comparing the structure of lorcai nide with oxi ramide (21). Anti arrhythmic oxi ramide... 

Still further simplification of the structural requirements for central analgesic activity came from the serendipitous observation that the simple phenyl pi peri dine, meperidine... 

Many polysaccharides of eukaryotic origin show non-specific anti-viral activity and this property may be shared by some of the exopolysaccharides. The structural requirements for activity are not immediately evident as the polysaccharides exhibiting this activity are very diverse. 

Discuss clearly the structural requirements for designing selective ionophores for ISE work. Give examples of such structures. 

The maturation of the precursor protein involves their proteolytic cleavage. There are two proteins important in this cleavage, so-called processing protease and protease enhancing peptide. These are now believed to be nonidentical subunits of the same enzyme. The structural requirements for recognition of the cleavage site are not fully understood and except for a positively charged residue at position (-2) there is no consensus sequence around this site. 

Pewnim T, Seifert J. 1993. Structural requirements for altering the L-tryptophan metabolism in mice by organophosphorous and methylcarbamate insecticides. Eur J Pharmacol 248 237-241. 

Structurally, plastomers straddle the property range between elastomers and plastics. Plastomers inherently contain some level of crystallinity due to the predominant monomer in a crystalline sequence within the polymer chains. The most common type of this residual crystallinity is ethylene (for ethylene-predominant plastomers or E-plastomers) or isotactic propylene in meso (or m) sequences (for propylene-predominant plastomers or P-plastomers). Uninterrupted sequences of these monomers crystallize into periodic strucmres, which form crystalline lamellae. Plastomers contain in addition at least one monomer, which interrupts this sequencing of crystalline mers. This may be a monomer too large to fit into the crystal lattice. An example is the incorporation of 1-octene into a polyethylene chain. The residual hexyl side chain provides a site for the dislocation of the periodic structure required for crystals to be formed. Another example would be the incorporation of a stereo error in the insertion of propylene. Thus, a propylene insertion with an r dyad leads similarly to a dislocation in the periodic structure required for the formation of an iPP crystal. In uniformly back-mixed polymerization processes, with a single discrete polymerization catalyst, the incorporation of these intermptions is statistical and controlled by the kinetics of the polymerization process. These statistics are known as reactivity ratios. 

Ozoe Y, Matsumura F. 1986. Structural requirements for bridged bicyclic compounds acting on picrotoxinin receptor. J Agric Food Chem 34 126-134. 

Bertolotti-Ciarlet, A., White, L. J., Chen, R., Prasad, B. V., and Estes, M. K. (2002). Structural requirements for the assembly of Norwalk virus-like particles. /. Virol. 76, 4044- 1055. 

The first substrate analogue inhibitors of FAAH were reported in 1994. The anandamide analogues prepared represented three elasses of putative transition-state inhibitors a-trifluoromethyl ketones, a-ketoesters and a-ketoamides [62], In the initial sereening studies, it was found that the trifluoromethyl ketone eompounds tested were effeetive inhibitors of AEA hydrolysis. A selected set of a-keto esters also inhibited hydrolysis, while a-keto amides were ineffective. In particular, arachidonyl trifluoromethyl ketone (32), gave almost 100% inhibition of anandamide hydrolysis. A detailed investigation of the structural requirements for FAAH inhibition with a-trifluoromethyl ketones has been carried out by Roger and co-workers [63]. 

K. Mizutani, T. Electronic and structural requirements for metabolic activation of butylated hydroxytoluene analogs to their quinone methides, intermediates responsible for lung toxicity in mice. Biol. Pharm. Bull. 1997, 20, 571-573. (c) McCracken, P. G. Bolton, J. L. Thatcher, G. R. J. Covalent modification of proteins and peptides by the quinone methide from 2-rm-butyl-4,6-dimethylphenol selectivity and reactivity with respect to competitive hydration. J. Org. Chem. 1997, 62, 1820-1825. (d) Reed, M. Thompson, D. C. Immunochemical visualization and identification of rat liver proteins adducted by 2,6-di- m-butyl-4-methylphenol (BHT). Chem. Res. Toxicol. 1997, 10, 1109-1117. (e) Lewis, M. A. Yoerg, D. G. Bolton, J. L. Thompson, J. Alkylation of 2 -deoxynucleosides and DNA by quinone methides derived from 2,6-di- m-butyl-4-methylphenol. Chem. Res. Toxicol. 1996, 9, 1368-1374. 

Mizutani, T. Ishida, I. Yamamoto, K. Tajima, K. Pulmonary toxicity of butylated hydroxytoluene and related alkylphenols structural requirements for toxic potency in mice. Toxicol. Appl. Pharmacol. 1982, 62, 273-281. 

Mizutani, T. Satoh, K. Nomura, H. Hepatotoxicity of eugenol and related compounds in mice depleted of glutathione structural requirements for toxic potency. Res. Commun. Chem. Pathol. Pharmacol. 1991, 73, 87-95. 

MacGregor, J. T. Jurd, L. Mutagenicity of plant flavonoids structural requirements for mutagenic activity in Salmonella typhimurium. Mutat. Res. 1978, 54, 297-309. 

Lagane B, Ballet S, Planchenault T, et al. Mutation of the DRY motif reveals different structural requirements for the CC chemokine receptor 5-mediated signaling and receptor endocytosis. Mol Pharmacol 2005 67(6) 1966-1976. 

In this review the definition, symmetry and structural requirements for formation of helical canal inclusion networks are introduced from a crystallographic viewpoint and then individual chemical systems are examined in detail. 

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