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Drug development structural genomics

In summary, in silica needs to embrace the complexity of the several membrane permeation processes that occur in viva, in order to provide the drug developers with a pure in silica decision making tool, which can predict in vivo endpoints for specific genomic profiles, exclusively from a compound s molecular structure. [Pg.135]

Fedorov O, Sundstrom M, Marsden B et al (2007) Insights for the development of specific kinase inhibitors by targeted structural genomics. Drug Discov Today 12 365-372... [Pg.38]

As a complex disorder with multifactorial clinical features, Alzheimer s disease (AD) needs to be studied in the context of diverse environmental impacts, cerebrovascular dysfunction, epigenetic phenomena, as well as various structural and functional genomic dysfunctions (see Chapter 13). This book provides a comprehensive and detailed discussion of the pharmacogenomics of AD, from functional genomics to therapeutic strategies, from the discovery of reliable biomarkers to the optimized drug development. [Pg.723]

Dekker, F. J., Koch, M. A., Waldmann, H. Protein structure similarity clustering (PSSC) and natural product structure as inspiration sources for drug development and chemical genomics. Curr. Opin. Chem. Bio. 2005, 9, 232-239. [Pg.208]

Theoretical models of bio-macromolecules are concerned with the development of efficient drugs, the mechanisms of signal transduction, and gene regulation by transcription factors. All these phenomena have in common the capital role played by intermolecular interactions between tlie partners and their ability to recognize patterns. The current developments in structural genomics are, however, continuously... [Pg.301]

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