Structural analogs antipsychotic drugs

Drug discrimination has also been used to compare antipsychotic drugs that act through different receptor mechanisms. The close structural analogs olanzapine and quetiapine... 

SAR Terfenadine was discovered in the course of an extensive and intensive search for new butyrophenone antipsychotic drugs as could be seen by the presence of the N-phenylbutanol substituent. It is also studded with a diphenylmethyl piperidine group structural analogous as is normally observed in the piperazine antihistaminies. 

Figure 9.2 Structural analogs of classical bioisosteric replacement of antipsychotic drugs.

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