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Drug design lead’ structure selection

Murray CW, Clark DE, Auton TR, Firth MA, Li J, Sykes RA, Waszkowycz B, Westhead DR, Young SC. PRO SELECT combining structure-based drug design and combinatorial chemistry for rapid lead discovery. J Comput Aided Mol Des 1997 11 193-207. [Pg.371]

Westhead, and S. C. Young,/. Comput.-Aided Mol. Des., 11, 193 (1997). PRO SELECT Combining Structure-Based Drug Design and Combinatorial Chemistry for Rapid Lead Discovery. 1. Technology. [Pg.53]

Since drug design and CombC involve the modelling of the relation between chemical structure and biological activity, it is essential that the investigated compounds span the pertinent space representing the structural variation in a reasonable way. This leads to the use of SMD for the selection of these compounds, as further discussed below. [Pg.202]

See other pages where Drug design lead’ structure selection is mentioned: [Pg.726]    [Pg.364]    [Pg.445]    [Pg.15]    [Pg.209]    [Pg.208]    [Pg.457]    [Pg.321]    [Pg.306]    [Pg.345]    [Pg.207]    [Pg.164]    [Pg.266]    [Pg.354]    [Pg.1281]    [Pg.589]    [Pg.1281]    [Pg.8]    [Pg.280]    [Pg.265]    [Pg.559]    [Pg.584]    [Pg.591]    [Pg.46]    [Pg.47]    [Pg.83]    [Pg.45]    [Pg.2]    [Pg.228]    [Pg.123]    [Pg.172]    [Pg.221]    [Pg.170]    [Pg.617]    [Pg.57]    [Pg.94]    [Pg.172]    [Pg.147]    [Pg.377]    [Pg.375]    [Pg.265]    [Pg.971]    [Pg.14]    [Pg.120]    [Pg.341]   
See also in sourсe #XX -- [ Pg.47 , Pg.79 ]



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Design structures

Drug selection

Drug structure

Lead selection

Lead structure

Leads, lead structures

Selective design

Selectivity, drug

Structural selection

Structure designable

Structure drug design

Structure lead structures

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