Platinum anticancer drugs structure—activity relationships

Platinum Anticancer Drugs Structure-Activity Relationships and Complexes on Clinical Trials Y... 

Farrell, N. P. Qu, Y. Bierbach, U. Valsecchi, M. Menta, E. Structure-activity Relationships within Di- and Trinuclear Platinum Phase I Clinical Agents In Cisplatin Chemistry and Biochemistry of a Leading Anticancer Drug Lippert, B., Ed. Verlag, 1999, pp 479 196. 

The early empirical structure-activity relationships promoted discovery of second-generation anticancer drugs such as complexes 2 and 3. However, analogs of these drugs usually display similar clinical profiles to the parent drugs. Therefore new classes of platinum complexes are required with distinct properties. 

N. Farrell, Y. Qu, U. Bierbach, M. Valsecchi, and E. Menta, Structure-activity Relationships Within Di-and Trinuclear Platinum Phase-I Clinical Anticancer Agents, in 30 Years of Cisplatin, Chemistry and Biochemistry of a Leading Anticancer Drug , ed. B. Lippert, Wiley VCH, Weinheim, 1999, p. 479. 

Current Status of Structure-Activity Relationships of Platinum Anticancer Drugs Activation of the trans-Geometry Nicholas Farrell... 

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