Structure-based drug design protein crystallography

Protein Crystallography in Structure-Based Drug Design... 

Qiu, X. and Abdel-Meguid, S. S. (2004). Protein crystallography in structure-based drug design. In Drug Discovery... 

Crystal structure of a protein molecule can also be determined by x-ray crystallography. Purified protein is crystallized either by batch methods or vapor diffusion. X-rays are directed at a crystal of protein. The rays are scattered depending on the electron densities in different positions of a protein. Images are translated onto electron density maps and then analyzed computationally to construct a model of the protein. It is especially important for structure-based drug designs. 

RC, S., Development of high-throughput technologies for protein crystallography and structure-based drug design. Abstracts of the Papers of the American Chemical Society 2001, 221 (2), U38. 

Mooij, W. T. M., Hartshorn, M. J., Tickle, I. J., Sharff, A. J., Verdonk, M. L., Jhoti, H. Automated protein-ligand crystallography for structure-based drug design. Chem. Med. Chem. 2006,1, 827-838. 

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