Steps in Structure-Based Drug Design

Major Steps in Structure-Based Drug Design 

The terminology structure-based drug design actually refers to the fundamental fact that exprimental structural data pertaining to the macromolecule of the drug-receptor complex is essentially involved in the modeling phenomenon explicitely. 

Importantly, the choice of CADD methods which may be applicable directly to drug design exclusively depends upon the availability of actual viable receptor information(s). In fact, the structure-based drug design proves to be of great help provided the ensuing receptor structure has been carefully and meticulously characterized by either high-resolution NMR-spectroscopy or X-ray 

One may consider the following major steps in the structure-based drug design, namely  

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High resolution x-ray crystallographic structure determination is an essential step in structure-based drug design. The need for high resolution structural data... 

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