Structure-activity relationship anti-cancer drugs

Beard A R, Drew M G B, Hilgard P, Hudson B D, Mann J, Neidle S, Wong L T F 1987 Podophyllotoxin analogues Synthesis and computer-modelling investigation of structure-activity relationships. Anti-Cancer Drug Des 2 247-252... 

Keskin O, Bahar I, Jernigan RL et al. Characterization of anti-cancer agents by their growth inhibitory activity and relationships to mechanism of action and structure. Anti-Cancer Drug Design 2000 15 79-98. 

Concurrent with the clinical development of cisplatin, an intense synthetic program to develop structure-activity relationships was initiated. Apart from the importance of this work in the understanding of the mechanism of action of cisplatin, the systematic search for analogues derived from a clinically-used compound provides an important source of new compounds [45]. For instance, of 22 new drugs introduced into clinical trials by the National Cancer Institute in the four-year period from 1975, eight were analogues of previously tested anti-cancer agents. 

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