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Rational drug design lead structure compounds

The nature of the action of antimetabolites means that a rational starting point for the design of new drugs is the structure of the normal metabolites used by the cell (Table 7.5). Consequently, SAR studies based on the endogenous metabolite supported by combinatorial synthesis and molecular modelling offer logical routes to new lead compounds and ultimately new drugs. [Pg.148]

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Compound, compounds design

Design structures

Drug rational

Drug structure

Drugs lead compound

Lead compounds

Lead structure

Leads, lead structures

Rational

Rational design

Rationalism

Rationally designed drug

Structure designable

Structure drug design

Structure lead structures