Chronic fatigue syndrome fibromyalgia and

Aaron LA, Burke MM, Buchwald D. Overlapping conditions among patients with chronic fatigue syndrome, fibromyalgia, and temporomandibular disorder. Arch Intern Med 2000 160 221-227. 

Jason LA, Taylor RR, Kennedy CL. Chronic fatigue syndrome, fibromyalgia and multiple chemical sensitivities in a community-based sample from persons with chronic fatigue-like symptoms. Psychosomatic Med2000 62 655-63. 

Guglielmi RS, Cox D], Spyker DA Behavioral treatment of phobic avoidance in multiple chemical sensitivity. ] Behav Ther Exp Psychiatry 25 197-209, 1994 Gupta K, Horne R The influence of health beliefs on the presentation and consultation outcome in patients with chemical sensitivities. J Psychosom Res 50 131-137,2001 Haller E Successful management of patients with multiple chemical sensitivities on an inpatient psychiatric unit. ] Clin Psychiatry 54 196-199, 1993 Jason LA, Taylor RR, Kennedy CL Chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities in a community-based sample of persons with chronic fatigue syndrome-like symptoms. Psychosom Med 62 655-663, 2000 Kaplan BJ, McNicol J, Conte RA, et al Dietary replacement in preschool-aged hyperactive boys. Pediatrics 83 7-17, 1989... 

If I m having a bad day I sometimes still write, unless a reaction to a chemical is affecting my brain. When I can t think clearly, I can t write. And sometimes I feel so apathetic that I can t write. But I m thankful that I have the skill. I think education is so important to prevent others from getting this illness. I believe that chronic fatigue syndrome, fibromyalgia, sick building syndrome and similar conditions with other names are all forms of MCS. They ll find that out with more studies. People just don t know what s wrong with them. They think they ve got asthma, depression, attention deficit disorder and a lot of other problems that can be related to chemical exposures. 

The idea of reduced adrenal capacity as a possible model for PTSD has also been recently raised by Heim et ah, who concluded that low cortisol may not be a unique feature of PTSD, but may represent a more universal phenomenon related to bodily disorders, having an etiology related to chronic stress (Heim et al. 2000). There are numerous stress-related disorders such as chronic fatigue syndrome, fibromyalgia, rheumatoid arthritis, chronic pain syndromes, and other disorders that are characterized by hypocortisolism. In one study, Heim et al. showed decreased cortisol responses to low-dose DEX, but failed to observe blunted ACTH responses to CRF in women with chronic pelvic pain, some of whom had PTSD, compared to women with infertility (Heim et al. 1998). Since the data were not analyzed on the basis of the subgroup with and without trauma and/or PTSD, it is not possible to directly compare results of that study to other reports examining PTSD directly. 

Frequently, MCS involves imbalances in one s nervous, immune, and endocrine systems, and impaired detoxification abilities. Conditions such as CFIDS (Chronic Fatigue Immune Dysfunction Syndrome), fibromyalgia, and Candida Syndrome are frequently found in people with MCS. It is not yet known whether these are separate diseases or whether they represent different manifestations of a common underlying problem. 

Neuroanatomically both the locus coeruleus and the raphe nuclei project to the spinal cord where they gate sensory pathways from the skeletomuscular areas. As there is evidence that both noradrenaline and 5-HT are dysfunctional in depression, it is perhaps not surprising to find that the pain threshold is often reduced in patients with depression. Conversely, different types of antidepressants have been shown to have an antinociceptive effect in both rodent models of neuropathic pain, and clinically in fibromyalgia, chronic fatigue syndrome, postherpetic neuralgia and diabetic neuropathy. In general, it would appear that the dual action antidepressants (such as the TCAs and SNRIs) are more effective than the SSRIs. 

Moldofsky H. Fibromyalgia, sleep disorder and chronic fatigue syndrome. Ciba Found Symp 1993 173 262-271. 

Schaefer KM. Sleep disturbances and fatigue in women with fibromyalgia and chronic fatigue syndrome. J Obstetric, Gynecologic, Neonat Nursi 1995 24 229-233. 

Pascualy R, Buchwald D. Chronic fatigue syndrome and fibromyalgia. In Kryger MH, Roth T, Dement WC, eds. Principles and Practice of Sleep Medicine. Philadelphia WB Saunders, 2000 1040-1049. 

Parker AJ, Wessely S, Cleare AJ. The neuroendocrinology of chronic fatigue syndrome and fibromyalgia. Psychol Med 2001 31 1331-1345. 

Co-Cure Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/ CFS) and Fibromyalgia www.co-cure.org... 

In an evaluation of the frequency and clinical characteristics of the underlying connective tissue disorders associated with silicone breast implants, 300 women with silicone breast implants were studied (45). In addition to a history and physical examination, C reactive protein, rheumatoid factor, and autoantibodies were determined. Criteria for fibromyalgia and/or chronic fatigue syndrome were met by 54% connective tissue diseases were detected in 11% and undifferentiated connective tissue disease or human adjuvant disease in 10.6%. A variety of disorders, such as angioedema, frozen shoulder, and a multiple sclerosis-like syndrome, were also found. Several other miscellaneous conditions, including recurrent and unexplained low grade fever, hair loss, skin rash, symptoms of the sicca sjmdrome, Rajmaud s phenomenon, carpal tunnel syndrome, memory loss, headaches, chest pain, and shortness of breath were also seen. Of 93 patients who underwent explantation, 70% reported improvement in their systemic symptoms. 

Mood disorders are commonly seen in general medical practice and some general medical disorders resemble depression in important respects. In particular, both fibromyalgia and chronic fatigue syndrome are medical disorders that have clinical and pathophysiologic features in common with atypical depression. 

Chemical Sensitivity Multiple Chemical Sensitivity (MCS), Chronic Fatigue Syndrome (CFS), Fibromyalgia (FM), and Gulf War Syndrome (GWS)... 

Individuals with chemical sensitivity, also referred to as chemical intolerance, are those who react adversely to low levels of chemicals that are tolerated by the general population. These include Multiple Chemical Sensitivity (MCS), Chronic Fatigue Syndrome (CFS), Fibromyalgia (FM), and Gulf War Syndrome (GWS). Each is a clinically defined condition that can give rise to chemical sensitivity, but there is, however, considerable comorbidity between them. Each is addressed individually, followed by a discussion of its similar responses to chemical stimuli. 

Tanriverdi F, Karaca Z, Unluhiarci K, Kelestimur F. The hypothalamo pituitary-adrenal axis in chronic fatigue syndrome and fibromyalgia syndrome. Stress 2007 10(1) 13-25. 

Pall ML. Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite. Med Hypotheses 2001 57(2) 139-45. 

Bell IR, Baldwin CM, Schwartz GE. Illness from low levels of environmental chemicals Relevance to chronic fatigue syndrome and fibromyalgia. Am J Med 1998 105(3A) 74S-82S. 

Brown MM, Jason, LA. Functioning in individuals with chronic fatigue syndrome Increased impairment with co-occurring multiple chemical sensitivity and fibromyalgia. Dyn Med 2007 6(1) 6, www.dynamic-med.com/ content/6/1/6... 

Table 18-1 lists the various names given to MCS. The most recent name for MCS is idiopathic environmental intolerances, or IEI (Bornschein et al. 2001). The variety of names reflects the unresolved definition of MCS. A survey of physicians familiar with MCS proposed six characteristics of MCS, as listed in Table 18-2 (Bartha et al. 1999). Table 18-3 lists the most frequent symptoms. MCS symptoms often overlap with symptoms of chronic fatigue syndrome and fibromyalgia (Jason et al. 2000 Nawab et al. 2000). Prevalence of MCS in community surveys and occupational health clinics was found to be 6.3% and 23.0%, respectively (Kreutzer et al. 1999 Kutsogiannis and Davidoff 2001). 

Fibromyalgia is a newer word connoting severe muscle pain, as distinguished from the joint pain of arthritis or rheumatism. Other symptoms such as depression and anxiety may also occur, and may include loss of sleep and flu-hke symptoms, hence the catchall term fibromyalgia syndrome. There is an overlap with symptoms of chronic fatigue syndrome [CFS].)... 

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