Sensory gating

Studies reveal that a homozygous GlyT-1 (-/-) knockout in mice is neonatally lethal. However heterozygous GlyT-1 (+/-) mice survive to adulthood and display enhanced NMDA receptor function in the hippocampus, better memory retention, and no disruption in sensory gating when dosed with amphetamine [15]. 

Acri JB, Morse DE, Popke EJ, Grunberg NE. (1994). Nicotine increases sensory gating measured as inhibition of the acoustic startle reflex in rats. Psychopharmacology (Berlin). 114(2) 369-74. 

Faraday MM, Rahman MA, Scheufele PM, Grunberg NE. (1998). Nicotine administration impairs sensory gating in Long-Evans rats. Pharmacol Biochem Behav. 61(3) 281-89. 

Adler LE, Pachtman E, Eranks RD, et al Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia. Biol Psychiatry... 

Adler LE, Hoffer LD, Griffith J, et al Normalization of the deficient auditory sensory gating in the relatives of schizophrenics by nicotine. Biol Psychiatry 32 607-616,... 

Talamini, L.M., Ellenbroek, R, Koch, T., Korf, J.. Impaired sensory gating and attention in rats with developmental abnormalities of the mesocortex. Implications for schizophrenia. Aim. NY Acad. ScL 911, 486-494, 2000. 

On each experimental day, the Repeatable Battery for Assessment of Neuropsychological Status (RBANS) was administered (Randolph, 1998). It assesses attention, immediate memory, visuospatial/ construction, language, and delayed memory (Gold et al., 1999). Schizophrenics score significantly lower than normal subjects the decrement is correlated with diminished psychosocial status. Compared to placebo, the DMXB-A significantly improved overall performance and specifically improved function on the Attention subscale. Inhibition of the P50 response to repeated stimulus, the sensory gating measure that led to identification of nicotinic receptor deficits in schizophrenia, also improved (Olincy et al., 2006). 

Houy E. et al. 2004. The promoter -194 C polymorphism of the nicotinic alpha 7 receptor gene has a protective effect against the P50 sensory gating deficit. Mol Psychiatry 9 ... 

Raux G, Bonnet-Brilhault F, Louchart S, et al. 2002. The -2bp deletion in exon 6 of the alpha 7-like nicotinic receptor subunit gene is a risk factor for the P50 sensory gating deficit. Mol Psychiatry 7 1006-1011. 

NMDA antagonists reliably induce deficits in sensory gating measures, such as prepulse inhibition (PPI) that closely mimic the deficits seen in schizophrenia in both rodent (de Bruin et al., 1999 ... 

Boeijinga PH, Soufflet L, Santoro F, Luthringer R. 2007. Ketamine effects on CNS responses assessed with MEG/ EEG in a passive auditory sensory-gating paradigm An attempt for modelling some symptoms of psychosis in man. J Psychopharmacol 21 321-337. 

Oranje B, Gispen-de Wied CC, Verbaten MN, Kahn RS. 2002. Modulating sensory gating in healthy volunteers The effects of ketamine and haloperidol. Biol Psychiatry 52 ... 

Adler LE, Waldo MC. 1991. Counterpoint A sensory gating-hippocampal model of schizophrenia. Schizophr Bull 17(1) 19-24. 

Bickford-Wimer PC, Nagamoto H, Johnson R, Adler LE, Egan M, Rose GM, Freedman R. 1990. Auditory sensory gating in hippocampal neurons A model system in the rat. Biological Psychiatry 27 183-192. 

Tregellas JR, Davalos DB, Rojas DC, Waldo MC, Gibson L, et al. 2007. Increased hemodynamic response in the hippocampus, thalamus and prefrontal cortex during abnormal sensory gating in schizophrenia. Schizophr Res 92 262-272. 

Thoma RJ, Hanlon FM, Sanchez N, Weisend MP, Huang M, et al. 2004. Auditory sensory gating deficit and cortical thickness in schizophrenia. Neurol Clin Neurophysiol... 

Adler LE, Olincy A, Waldo M, Harris JG, Griffith J, Stevens K, Flach. 1998. Schizophrenia, sensory gating, and nicotinic receptors. Schizophrenia Bulletin 24 189-202. 

Adler LE, Rose G, Freedman R. 1986. Neurophysiological studies of sensory gating in rats Effects of amphetamine,... 

Boutros NN, Belger A, Campbell D, D Souza C, Krystal J. 1999. Comparison of four components of sensory gating in schizophrenia and normal subjects a preliminary report. Psychiatry Res 88 119-130. 

Boutros NN, Korzyukov O, Jansen B, Feingold A, Bell M. 2004. Sensory gating deficits during the mid-latency phase of information processing in medicated schizophrenia patients. Psychiatry Res 126 203-215. 

Ellenbroek BA, van Luijtelaar G, Frenken M, Cools AR. 1999. Sensory gating in rats Lack of correlation between auditory evoked potential gating and prepulse inhibition. Schizophr Bull 25 777-788. 

Judd LL, McAdams L, Budnick B, Braff DL. 1992. Sensory gating deficits in schizophrenia new results. Am J Psychiatry 149 488-493. 

Miyazato H, Skinner RD, Garcia-Rill E. 1999. Sensory gating of the P13 midlatency auditory evoked potential and the startle response in the rat. Brain Res 822 60-71. 

Moxon KA, Gerhardt GA, Adler LE. 2003. Dopaminergic modulation of the P50 auditory-evoked potential in a computer model of the CA3 region of the hippocampus its relationship to sensory gating in schizophrenia. Biol Cybem 88 265-275. 

Siegel C, Waldo M, Mizner G, Adler LE, Freedman R. 1984. Deficits in sensory gating in schizophrenic patients and their relatives. Evidence obtained with auditory evoked responses. Arch Gen Psychiatry 41 607-612. 

Stevens KE, Bullock AE, Collins AC. 2001. Chronic corticosterone treatment alters sensory gating in C3H mice. Pharmacol Biochem Behav 69 359-366. 

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