Capillary electrophoresis mass

A. J. Tomlinson and S. Naylor, Systematic development of on-line membrane preconcentration-capillary electrophoresis-mass spectrometry foi analysis of peptide mixtures, J. Capillary Electrophoresis 225-233 (1995). 

Figure 11.18 Schematic diagram of an in-line SPE unit for CE using (a) polyester wool frits to hold the sorbent, or (b) a paiticle-loaded membrane. Reprinted from Journal of Capillary Electrophoresis, 2, A. J. Tomlinson and S. Naylor, Enhanced performance membrane preconcenti ation-capillary electrophoresis-mass spectiometi y (mPC-CE-MS) in conjunction with ti ansient isotachophoresis for analysis of peptide mixtures, pp 225-233, 1995, with permission from ISC Teclmical Publications Inc.

As in HPLC, the coupling of MS detection with CE has provided an excellent opportunity for more selective analysis, but the much reduced flow rates, small injection volumes, limitations in the types of buffers used [since electrospray ionization (ESI) is used in capillary electrophoresis/mass spectrometry (CE/MS)], and need to... 

Issaq, H.J., Janini, G.M., Chan, K.C., Veenstra, T.D. (2004). Sheathless electrospray ionization interfaces for capillary electrophoresis—mass spectrometric detection advantages and limitations. J. Chromatogr. A 1053, 37 42. 

Rodriguez, R., Manes, J., Pico, Y. (2003). Off-line solid-phase microextraction and capillary electrophoresis mass spectrometry to determine acidic pesticides in fruits. Anal. Chem. 75, 452 159. 

Riu et al. [542] has reported the determination of linear ethyl benzane-sulfates in coastal waters using automated solid-phase extraction followed by capillary electrophoresis with ultraviolet detection, and confirmed by capillary electrophoresis-mass spectrometry. The detection limits were 1 pg/1 when 250 ml of coastal water was preconcentrated. 

The sensors in this section can also be utilized to detect chemicals in liquid through the bulk solution refractive index change induced by the presence of target chemicals. Since no recognition molecules are used, this type of chemical sensing may usually have low specificity. However, these sensors may perform excellently in conjunction with other technologies such as capillary electrophoresis, mass spectrometer, and liquid chromatography in chemical detection. 

T. Poiger, S.D. Richardson and G.L. Baughman, Identification of reactive dyes in spent dye-baths and wastewater by capillary electrophoresis-mass spectrometry. J. ChromatogrA, 886 (2000) 271-282. 

Zamfir A, Peter-KataUnic J. 2004. Capillary electrophoresis-mass spectrometry for glycoscreening in biomedical research. Electrophoresis 25 1949. 

Valaskovic M, KeUeher NK, McLafferty FW. 1996. Attomole protein characterization by capillary electrophoresis—mass spectrometry. Science 273 1199-1202. 

Bendahl, L., Hansen, S. H., and Gammelgaard, B. (2001). Capillary modified by noncovalent anionic polymer adsorption for the capillary zone electrophoresis, micellar electrokinetic capillary chromatography and capillary electrophoresis mass spectrometry. Electrophoresis 22, 2565-2573. 

Hernandez-Borges, J., NeusiiB, C., Cifuentes, A., and Peking, M. (2004). On-line capillary electrophoresis-mass spectrometry for the analysis of biomolecules. Electrophoresis 25, 2257-2281. 

Monton, M. R. N., and Terabe, S. (2005). Recent developments in capillary electrophoresis-mass spectrometry of proteins and peptides. Anal. Sci. 21, 5 — 13. 

Visky, D., Jimidar, I., Van Ael, W., Vennekens, T., Redlich, D., and De Smet, M. (2005). Capillary electrophoresis-mass spectrometry in impurity profiling of pharmaceutical products. Electrophoresis 26, 1541-1549. 

Unger, M., Stockigt, D., Beider, D., and Stockigt, J. (1997). General approach for the analysis of various alkaloid classes using capillary electrophoresis and capillary electrophoresis mass spectrometry. /. Chromatogr. A 767, 263—276. 

Huggins, T. G., and Henion, J. D. (1993). Capillary electrophoresis/mass spectrometry determination of inorganic ions using and ion spray-sheath flow interface. Electrophoresis 14, 531 — 539. 

Moini, M. (2002). Capillary electrophoresis mass spectrometry and its application to the analysis of biological mixtures. Anal. Bioanal. Chem. 373, 466-480. 

Ross, G. A. (2001). Capillary electrophoresis-mass spectrometry. Practical implementation and applications. LC-GC Eur. 14, 45—49. 

Smith, R. D., Goodlett, D. R., and Wahl, J. H. (1994). Capillary Electrophoresis-Mass Spectrometry A Practical Approach. In Handbook of Capillary Electrophoresis (J. P. Landers, Ed), pp. 185—206, CRC Press, Boca Raton, EL. 

Mordehai, A., Lim, H. K., and Henion, J. D. (1995). Ion-spray liquid-chromatography mass-spectrometry and capillary electrophoresis mass-spectrometry on a modified benchtop ion-trap mass-spectrometer. In Practical Aspects of Ion-Trap Mass Spectrometry Chemical, Environmental and Biomedical Applications (R. E. March, and J. F. J. Todd, Eds), Vol. 3, pp. 215—237, CRC Press, Boca Raton, FL. 

Schmitt-Kopplin, P., and Frommberger, M. (2003). Capillary electrophoresis-mass spectrometry 15 years of developments and applications. Electrophoresis 24, 3837—3867. 

Bemet, P., Blaser, D., Berger, S., and Schaer, M. (2004). Development of a robust capillary electrophoresis-mass spectrometer interface with a floating sheath liquid feed. Chimia (Aarau) 58, 196-199. 

Kolch, W., Neususs, C., Pelzing, M., and Mischak, H. (2005). Capillary electrophoresis-mass spectrometry as a powerful tool in clinical diagnosis and biomarker discovery. Mass Spectrom. Rev. 24, 959-977. 

Nilsson, S. L., Bylund, D., Joernten-Karlsson, M., Petersson, P., and Markides, K. E. (2004). A chemometric study of active parameters and their interaction effects in a nebulized sheath-liquid electrospray interface for capillary electrophoresis-mass spectrometry. Electrophoresis 25, 2100-2107. 

Jussila, M., Sinervo, K., Porras, S. P, and Riekkola, M. L. (2000). Modified liquid-junction interface for nonaqueous capillary electrophoresis-mass spectrometry. Electrophoresis 21, 3311—3317. 

Liu, C. C., Jong, R., and Covey, T. (2003). Coupling of a large-size capillary column with an electrospray mass spectrometer. A reliable and sensitive sheath flow capillary electrophoresis-mass spectrometry interface.. Chromatogr. A 1013, 9-18. 

Wachs, T., Sheppard, R. L., and Henion, J. (1996). Design and applications of a self-aligning liquid junction-electrospray Interface for capillary electrophoresis-mass spectrometry. /. Chromatogr. B 685, 335-342. 

Kele, Z., Eerenc, G., Klement, E., Toth, G. K., and Janaky, T. (2005). Design and performance of a sheathless capillary electrophoresis/mass spectrometry Interface by combining fused-slllca capillaries with gold-coated nanoelectrospray tips. Rapid Commun. Mass Spectrom. 19, 881 — 885. 

Waterval, J. C. M., Bestebreurtje, P., Lingeman, H., Versluis, C., Heck, A. J. R., Bult, A., and Underberg, W. J. M. (2001). Robust and cost-effective capillary electrophoresis-mass spectrometry interfaces suitable for combination with on-line analyte preconcentration. Electrophoresis 22, 2701-2708. 

Goodwin, L., Startin, J. R., Keely, B. J., and Goodall, D. M. (2003). Analysis of glyphosate and glufosinate by capillary electrophoresis-mass spectrometry utilizing a sheathless microelectrospray interface./. Chromatogr. A 1004, 107—119. 

Trapp, O., Pearce, E. W., Kimmel, J. R., Yoon, O. K., Zuleta, I. A., and Zare, R. N. (2005). A soft on-column metal coating procedure for robust sheathless electrospray emitters used in capillary electrophoresis-mass spectrometry. Electrophoresis 26, 1358-1365. 

Herring, C. J., and Qin, J. (1999). An online preconcentrator and the evaluation of electrospray interfaces for the capillary-electrophoresis mass-spectrometry of peptides. Rapid Commun. Mass... 

Mccomb, M. E., and Perreault, H. (2000). Design of a sheathless capillary electrophoresis-mass spectrometry probe for operation with a Z-Spray ionization source. Electrophoresis 21, 1354-1362. 

Janini, G. M., Conrads, T. P., Wilkens, K. L., Issaq, H. J., and Veenstra, T. D. (2003). A sheathless nanoflow electrospray interface for on-line capillary electrophoresis mass spectrometry. Anal. Chem. 75, 1615-1619. 

Tanaka, Y., Otsuka, K., and Terabe, S. (2003). Evaluation of an atmospheric pressure chemical Ionization Interface for capillary electrophoresis-mass spectrometry. /. Pharm. Biomed. Anal. 30, 1889-1895. 

Mol, R., de Jong, G. J., and Somsen, G. W. (2005). Online capillary electrophoresis-mass spectrometry using dopant-assisted atmospheric pressure photoionization setup and system performance. Electrophoresis 26, 146—154. 

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