Capillary zone electrophoresis-mass

ONLINE REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY-CAPILLARY ZONE ELECTROPHORESIS - MASS SPECTROMETRY... 

Gysler, J., Mazereeuw, M., Helk, B., Heitzmann, M., Jaehde, U., Schunack, W., Tjaden, U.R., and van der Greef, J., Utility of isotachophoresis-capillary zone electrophoresis, mass spectrometry and high-performance size-exclusion chromatography for monitoring of interleukin-6 dimer formation, /. Chromatogr. A, 841, 63, 1999. 

Smith, R. D., Olivares, J. A., Nguyen, N. T., and Udseth, H. R., Capillary zone electrophoresis-mass spectrometry using an electrospray ionization interface, Anal. Chem., 60, 436, 1988. 

Smith, R.D., Barinaga, J.C., Udseth, H.R. (1988). Improved electrospray ionization interface for capillary zone electrophoresis-mass spectrometry. Anal. Chem. 60, 1948-1952. 

Boss H J., Watson D.B., and Rush R.S. (1998), Peptide capillary zone electrophoresis mass spectrometry of recombinant human erythropoietin an evaluation of the analytical method, Electrophoresis 19(15), 2654—2664. 

Hoitink, M. A., Hop, E., Beijnen, J. H., Bull, A., Kettenes-van den Bosch, J. J., and Underberg, W. J. M. (1997). Capillary zone electrophoresis mass spectrometry as a tool in the stability research of the luteinising hormone-releasing hormone analogue goserelin.. Chromatogr. A 776, 319—327. 

Nielen, M. W. F. (1995). Industrial applications of capillary zone electrophoresis mass spectrometry. /. Chromatogr. A 712, 269—284. 

Castro-Puyana, M., Garcia-Ruiz, C., Cifuentes, A., Crego, A.L., Marina, M.L.J. Identification and quantitation of cis-ketoconazole impurity by capillary zone electrophoresis-mass spectrometry. J. Chromatogr. A 1114, 170-177 (2006)... 

Smith, R. D. Maringa, C. J. Udseth, C. R. "Improved electrospray ionization interface for capillary zone electrophoresis/mass spectrometry" Anal. Chem. 1988, 60, pp 1948-1952. 

Other Techniques. A growing technique related to lc/ms and regarded as complementary to it is that of capillary zone electrophoresis/mass spectrometry (cze/ms) (22). Using cze/ms, high resolution separation of water-soluble compounds is accompHshed by the principles of electrophoresis (qv). The sample is then coupled to the mass spectrometer by electrospray ionization (23) or a fast atom bombardment interface (fab) to produce molecular ions (24). Biotechnology applications of cze/ms have great potential (25). 

Buscher, B.A.P., van der Hoeven, R.A.M., Tjaden, U.R., Andersson, E. and van der Greef, J. (1995) Analysis of inositol phosphates and derivatives using capillary zone electrophoresis-mass spectrometry. Journal of Chromatography A 712, 235-243. 

Zhu, J. and Feng, Y.L., A powered online enhancement technique for the analysis of nucleotides using capillary zone electrophoresis/mass spectrometry. Anal. Chem., 78, 6608, 2006. 

Moseley, M. A., Deterding, L. J., Tomer, K. B., and Jorgenson, J. W., Determination of bioactive peptides using capillary zone electrophoresis/mass spectrometry. Analytical Chemistry 1991, 63, 109-114. 

An on-line coupling of capillary electrophoresis or reversed anionic capillary isotachophoresis (CITP) with electrospray ionization mass spectrometry has been described for the separation of monophosphate nucleosides, pyridine, and flavin dinucleotides (87). The combination with CITP gives an enhancement of sample loadability and concentration sensitivity in capillary zone electrophoresis/ mass spectrometry (CZE/MS). MS-compatible buffer systems were developed (trailing electrolyte, 10 mM caproic acid pH 3.4 leading electrolyte, 7 mM HCl/ 13 mM P-alanine pH 3.9). This technique seems to be valuable for the trace analysis of DNA and RNA, e.g., to study radiation-induced DNA damage. 

Li 2002) determined sildenafil and its metabolite in human serum by capillary zone electrophoresis-mass spectrometry analysis using covalently bonded PMIM Q to a silica capillary. Scheme representation of the IL coating procedure is presented on Fig.l3. The adsorption of the analytes onto the bare capillary wall was eliminated by the IL coating and the drugs were baseline-sep)arated within 14 min with detection limits of 14 and 17 ng/mL for sildenafil and metabolite respectively. 

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