Research biomedical

Medline covers primarily biomedical literature, containing more than 13 million citations (October, 2002) of articles from more than 4600 journals published since 1958 [18]. The database covers basic biomedical research, clinical sciences, dentistry, pharmacy, veterinary medicine, pre-clinical sciences, and life science. Medline, a subset of PubMed, is a bibliographic database produced by the US Nationcil Library of Medicine (NLM). The database is available free of charge via SciFinder Scholar or PubMed [19]. 

PIR is produced by the National Biomedical Research Foundation (NBRF) [35]. 

PIR National Biomedical Research Form-dation protein sequence biblio., sub- stance, se- quence 280 000 protein sequences journals, author submis- sions National Biomedical Research Foundation free periodi- cally http //pir.geor- getown.edu... 

Each element of matrix corresponds to the probability that the amino acid in coiumn wiii mutate to the jmino acid in row j after a period of 1 PAM. The vaiues have been multipiied by 10000. (Based on Dayhoff M O 1978. Atlas of Protein Sequence and Structure Voiume 5 Suppiement 3. Dayhoff M O (Editor) Georgetown Jniversity Medicai Center, National Biomedical Research Foundation Figure 82.)... 

Dayhoff M 01978. A Model of Evolutionary Change. In Dayhoff M O (Editor) Proteins in A Has of F Sequence and Structure Volume 5 Supplement 3. Georgetown University Medical Center, Na Biomedical Research Foundation, pp. 345-358. 

Cotter, R.J., Time-of-Flight Mass Spectrometry Instrumentation and Applications in Biomedical Research, American Chemical Society, Washington, D.C., 1997. 

One of the newer and more fmitful developments in this area is asymmetric hydroboration giving chiral organoboranes, which can be transformed into chiral carbon compounds of high optical purity. Other new directions focus on catalytic hydroboration, asymmetric aHylboration, cross-coupling reactions, and appHcations in biomedical research. This article gives an account of the most important aspects of the hydroboration reaction and transformations of its products. For more detail, monographs and reviews are available (1—13). 

BIOBUSINESS Bio sis BRS, Data-Star, Dialog, STN biomedical research... 

Mass Spectrometer. The mass spectrometer is the principal analytical tool of direct process control for the estimation of tritium. Gas samples are taken from several process points and analy2ed rapidly and continually to ensure proper operation of the system. Mass spectrometry is particularly useful in the detection of diatomic hydrogen species such as HD, HT, and DT. Mass spectrometric detection of helium-3 formed by radioactive decay of tritium is still another way to detect low levels of tritium (65). Accelerator mass spectroscopy (ams) has also been used for the detection of tritium and carbon-14 at extremely low levels. The principal appHcation of ams as of this writing has been in archeology and the geosciences, but this technique is expected to faciUtate the use of tritium in biomedical research, various clinical appHcations, and in environmental investigations (66). 

We are grateful to Dr. Azat Badretdinov and Mr. Eric Feyfant for many discussions about comparative protein structure modeling. AF is a Burroughs Wellcome Fellow. RS is a Howard Hughes Medical Institute predoctoral fellow. FM is a Norman and Rosita Winston Biomedical Research Foundation Fellow. AS is a Sinsheimer Scholar and an Alfred P. Sloan Research Fellow. The investigations have also been aided by grants from NIH (GM 54762) and NSF (BIR-9601845). 

Many fluorinations by electropositive fluorine reagents produce a-fluoro carbonyl compounds as the final result An extensive review exists on the preparation of a-fiuorocarbonyl compounds [101 Also, electropositive reagents are used widely in the preparation of F-labeled radioactive materials required in positron etmssion tomography for biomedical research Excellent reviews are available on fluonne-18 labeling [//, 72]. 

Almost all of the biomedical research done in the 25 years following the liquid-breathing work was conducted with commercially available fluorocarbons manufactured for various industnal uses by the electrochemical Simons process (fluonnation in a hydrofluoric acid solution) or the cobalt fluoride process (fluori-nation with this solid in a furnace at about 200 C) These processes tended to yield many by-products, partly because they were, to some extent, free radical reactions and partly because it was difficult to easily achieve complete fluonnation Aromatic hydrocarbons gave better products with the cobalt tnfluonde [73] method, whereas saturated hydrocarbons yielded better products with fluonnation using diluted or cooled gaseous fluorine (Lagow) Incompletely fluormated matenal was either... 

Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi,... 

Klaus Seuwen, Marie-Gabrielle Ludwig Novartis Institutes for Biomedical Research, Switzerland... 

Psychiatry/Neuroscience Research Novartis Institutes for Biomedical Research Basel Basel... 

Trasitensin (Novartis Biomedical Research)- Tenolone (Lusofarmaco)-... 

The National Institute of Environmental Health Sciences (NIEHS) is the principal federal agency for biomedical research on the effects of chemical, physical, and biologic environmental agents on human health and well-being. ContactNAEiTS, PO Box 12233, 104 T.W. Alexander Drive, Research Triangle Park, NC 27709 Phone 919-541-3212. 

NLP systems are being developed to address the increasingly challenging problem of data mining for systems level content from the published literature, that is, integrating across the global expert database of biomedical research [71]. One recent approach to this problem was to develop a web-based tool, PubNet, that is able to visualize concept and theme networks derived from the PubMed literature [72]. 

Daniel Cronenberger, Novartis Institutes for BioMedical Research, Lichstrasse 35, 4002 Basel, Switzerland. 

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