Cancer tomatoes

Bladder cancer Tomato or lycopene does not reduce the risk of bladder cancer. 

GiovANNUcci E (1999) Tomatoes, tomato-based products, lycopene, and cancer review of the epidemiologic literature , J Natl Cancer Inst, 99, 317-31. 

An evaluation of the Health Professionals Follow-Up Study (Giovannucci et al., 1995) has detected a lower prostate cancer risk associated with the greater consumption of tomatoes and related food products. Tomatoes are the primary dietary source of lycopene and lycopene concentrations are highest in testis and adrenal tissue (Clinton, 1998). In paired benign and malignant prostate tissue from 25 American men, 53-74 yrs, undergoing... 

GIOVANNUCCI E, RIMM E B, LIU Y, STAMPFER M J and WILLETT w c (2002) A prospective study of tomato products, lycopene and prostate cancer risk , J Natl Cancer Inst, 94, 391-8. 

Carotenoids and prostate cancer — Numerous epidemiological studies including prospective cohort and case-control studies have demonstrated the protective roles of lycopene, tomatoes, and tomato-derived products on prostate cancer risk other carotenoids showed no effects. " In two studies based on correlations between plasma levels or dietary intake of various carotenoids and prostate cancer risk, lycopene appeared inversely associated with prostate cancer but no association was reported for a-carotene, P-carotene, lutein, zeaxanthin, or p-cryptoxanthin. - Nevertheless, a protective role of all these carotenoids (provided by tomatoes, pumpkin, spinach, watermelon, and citrus fruits) against prostate cancer was recently reported by Jian et al. ... 

Campbell, J.K. et al.. Tomato phytochemicals and prostate cancer risk, J. Nutr., 134, 3486S, 2004. 

Etminan, M. et al.. The role of tomato products and lycopene in the prevention of prostate cancer a meta-analysis of observational studies. Cancer Epidemiol. Biomarkers Prev., 13, 340, 2004. 

Chen, L. et al.. Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention, J. Natl. Cancer Inst., 93, 1872, 2001. 

Kucuk, O. et al.. Effects of lycopene supplementation in patients with localized prostate cancer, Exp. Biol. Med. (Maywood), 227, 881, 2002. van Breemen, R.B. et al.. Liquid chromatography-mass spectrometry of cis- and all-trans-lycopene in human serum and prostate tissue after dietary supplementation with tomato sauce, J. Agric. Food Chem., 50, 2214, 2002. 

Rao, A.V. and Agarwal, S., Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer, Nutr. Cancer, 3, 199, 1998. 

Other dietary factors implicated in prostate cancer include retinol, carotenoids, lycopene, and vitamin D consumption.5,6 Retinol, or vitamin A, intake, especially in men older than age 70, is correlated with an increased risk of prostate cancer, whereas intake of its precursor, [3-carotene, has a protective or neutral effect. Lycopene, obtained primarily from tomatoes, decreases the risk of prostate cancer in small cohort studies. The antioxidant vitamin E also may decrease the risk of prostate cancer. Men who developed prostate cancer in one cohort study had lower levels of l,25(OH)2-vitamin D than matched controls, although a prospective study did not support this.2 Clearly, dietary risk factors require further evaluation, but because fat and vitamins are modifiable risk factors, dietary intervention may be promising in prostate cancer prevention. 

Boileau, T. W., Z. Liao, S. Kim et al. 2003. Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets. J Natl Cancer Inst 95(21) 1578—1586. 

Bowen, P, L. Chen, M. Stacewicz-Sapuntzakis et al. 2002. Tomato sauce supplementation and prostate cancer Lycopene accumulation and modulation of biomarkers of carcinogenesis. Exp Biol Med (Maywood) 227(10) 886-893. 

Canene-Adams, K., B. L. Lindshield, S. Wang et al. 2007. Combinations of tomato and broccoli enhance antitumor activity in dunning r3327-h prostate adenocarcinomas. Cancer Res 67(2) 836-843. 

Population studies associate tomato consumption with reduced risk to prostate cancer. The most positive associations have come from cohort studies performed before the prostate-specific antigen (PSA)-screening era, and these studies have suggested that the tomato/lycopene effect was the strongest for clinically relevant prostate cancers (Giovannucci 2007). Small human studies have shown in vivo antioxidant effects for tomato products but evidence for lycopene alone is weak (Chen et al. 2001, Porrini and Riso 2000, Riso et al. 2004, Zhao et al. 2006). Animal and tissue culture studies have been... 

Giovannucci, E. 2007. Does prostate-specific antigen screening influence the results of studies of tomatoes, lycopene, and prostate cancer risk 7 Natl Cancer Inst 99(14) 1060-1062. 

Gitenay, D, B Lyan, J Talvas, A Mazur, S George, C Caris-Veyrat, and E Rock. 2007. Serum from rats fed red or yellow tomatoes induced Connexin-43 expression independently from lycopene in a prostate cancer cell line. Biochem Biophys Res Commun 364 578-582. 

Gustin, DM, Rodvold KA, Sosman JA et al. 2004. Single-does pharmakinetic study of lycopene delivered in a well-defined food-based lycopene delivery system (tomato pasted-oil mixture) in healthy adult male subjects. Cancer Epidemiol Biomarkers Prev 13(5) 850-860. 

Hwang, E-S and PE Bowen. 2005b. Effects of tomato paste extracts on cell proliferation, cell-cycle arrest and apoptosis in LNCaP human prostate cancer cells. Biofactors 23 75-84. 

A study at the Harvard School of Public Health done on 48,000 men for 4 years reported that men who ate 10 or more servings of tomato products (such as tomatoes, tomato sauce, pizza sauce) per week had up to 34% less chance to develop prostate cancer (Giovannucci and others 1995). They showed that lycopene intake from tomato-based products is related to a low risk of prostate cancer, but consumption of other carotenoids ((3-carotene, a-carotene, lutein, (3-cryptoxanthin) or retinol was not associated with the risk of prostate cancer. 

Franceschi S, Bidoli E, La Vecchis C, Talamini R, D Avanzo B and Negri E. 1994. Tomatoes and risk of digestive-tract cancers. Int J Cancer 59 181-184. 

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