Malignant prostate tissue

An evaluation of the Health Professionals Follow-Up Study (Giovannucci et al., 1995) has detected a lower prostate cancer risk associated with the greater consumption of tomatoes and related food products. Tomatoes are the primary dietary source of lycopene and lycopene concentrations are highest in testis and adrenal tissue (Clinton, 1998). In paired benign and malignant prostate tissue from 25 American men, 53-74 yrs, undergoing... 

Baffa R, Moreno JG, Monne M, Veronese ML, Gomella LG. A comparative analysis of prostate-specific antigen gene sequence in benign and malignant prostate tissue. Urology 1996 47 795-800. 

Petraki CD, Gregorakis AK, Papanastasiou PA, Karavana VN, Luo LY, Diamandis EP. Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues. Prostat CancerProstatic Dis 2003 6 223-227. 

The first study where the SCS was applied to MRS analysis of prostate biopsies was undertaken at the IBD in Winnipeg.42 Proton MRS (Bruker Instruments, 8.5 T were performed at 37°C on specimens of benign (n = 66) and malignant (n = 21) human prostate tissue specimens collected from transurethral resection of the prostate and radical prostatectomy from 50 patients. Typical spectra of malignant prostate tissue and benign prostate hyperplasia (BPH) are shown in Fig. 5.42 The spectral data were subjected to visual inspection analysis and multivariate analysis, specifically LDA. 

Wang and co-workers purified a protein from prostatic tissue and called it prostate-specific antigen. PSA is found in normal, benign, hyperplastic, and malignant prostatic tissues, y-seminoprotein, p30, and PSA are biochemically very similar. 

Absorption Component Shape Spectra Malignant Prostate Tissue... 

Lycopene has been reported [35-38] to accumulate predominantly in liver, adrenal, testicular, and prostate tissue (Table 3) in benign or malignant prostate tissue, mean lycopene concentrations of 0.8 nmol/g tissue have been measured, with up to 2.6 nmol/g being found in some individuals [36]. However, no significant correlation was observed between lycopene concentration and that of any other carotenoid. As for serum, the ratio of lycopene Z- to all E-isomers was higher in tissues [36] than in tomato-based foods. While local isomerization cannot be entirely excluded, no responsible enzyme has yet... 

C/5-isomers preferentially accumulate in tissnes, and all dietary carotenoids that are present in human seram may be accnmnlated in prostate. Lycopene and other major carotenoids have been shown to be present in higher concentrations in malignant prostate tissue relative to normal prostate tissue, although no apparent difference in the lycopene isomer ratio existed between benign and malignant tissnes S -trans lycopene 12 to 21% and cis isomers 79 to 88% of total lycopene). A hypothesis to explain this is that since the metabolism of the prostate is regulated by the neuroendocrine axis and uptake of... 

Chaudry, A.A., Wahle, K.W.J., McClinton, S., and Moffat, L.E.F. (1994) Arachidonic Acid Metabohsm in Benign and Malignant Prostatic Tissue In Vitro-. Effects of Fatty Acids and Cyclooxygenase Inhibitors, Int. J. Cancer 57, 176-180. 

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