Antigen prostate-specific

BARNES s (2001) The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigen. J Urol. 165 (1) 294-300. 

No association. - = Inverse association. + = Positive association. ATBC = a-Tocopherol, p-Carotene Cancer Prevention Study. PSA = Prostate-specific antigen. 

Intervention trials confirmed this protective role of lycopene on prostate cancer risk. Three primary intervention studies evaluated the effect of lycopene supplementation on prostate cancer risk or on certain risk markers such as prostate-specific antigen (PSA) plasma concentration or oxidative alterations of leucocyte DNA. - All showed increases of plasma and prostate lycopene levels after diet supplementation with lycopene and inverse correlations between tumor incidence and risk biomarkers. 

Serum prostate specific antigen (PSA) will be increased. 

Prostate-specific antigen (PSA) Blood test for this chemical secreted by the prostate Less than 4 ng/mL (4 mcg/L) Greater than or equal to 4 ng/mL (4 mcg/L)... 

Prostate-specific antigen (PSA) is a useful marker for detecting prostate cancer at early stages, predicting outcome for localized disease, defining disease-free status, and monitoring response to... 

EM = Expectant management RT = Radiation therapy RP = Radical prostatectomy PSA = Prostate specific antigen. 

Prostate-specific antigen (PSA) Less than 4 ng/mL 1 Less than 4 mcg/L... 

PSA Prostate-specific antigen Si First heart sound... 

Prostate-specific antigen (PSA) a substance secreted by the prostate and normally carried by ducts to the urethra during ejaculation PSA is used as a screening test for prostate cancer. 

Under this proposal, device manufacturers could choose to use horizontal standards for class II devices when an SCGD exists or when the FDA has recognized an individual special control such as relevant vertical standards (e.g., prostate-specific antigen). In addition to the required elements of a 510(k) (21 CFR 807.87), these applications could include summary information that describes how special controls have been used to address the risks associated with the device type and a declaration of conformity with any relevant recognized standard(s), as applicable. As expected, a declaration of conformity with a standard would provide a summary of a manufacturer s efforts to conform with the recognized standard and would outline any deviations specifying ... 

Carter, H. B., Epstein, J. I., Chen, D. W., et al. Recommended prostate-specific antigen testing intervals for the detection of curable prostate cancer. JAMA 227,1456-1460 (1997). 

Chen, Z., Prestigiacomo, A., Stamey, T. Purification and characterization of prostate-specific antigen (PSA) complexed to alpha-1 antichymotrypsin Potential reference material for international standardization of PSA immunoassays. Clin. Chem. 41, 1273-1282 (1995). 

Cuny, C., Pham, L., Kramp, W Sharp, T., Soriano, T. F. Evaluation of a two-site immunoradio-metric assay for measuring noncomplexed (free) prostate-specific antigen. Clin. Chem. 42, 1243-1249 (1996). 

Diamandis, E. P., Yu, H., Melegos, D. N. Ultrasensitive prostate-specific antigen assays and their clinical application. Clin. Chem. 42,853-864 (1996). 

Ferguson, R. A., Diamandis, E. P. Ultrasensitive detection of prostate-specific antigen by a time-resolved immunofluorometric assay and the immunochemiluminescent third-generation assay. Clin. Chem. 42,203-212 (1996). 

Honda, S. A., Golstein, A. P Bhagavan, N. V. Prostate-specific antigen concentrations in serum in acute illnesses, Clin. Chem. 42,1785-1788 (1996). 

Junker, R., Brandt, B Zechel, C Assmann, G. Comparison of prostate-specific antigen (PSA) measured by four combinations of free PSA and total PSA assays. Clin. Chem. 43, 1588-1594... 

Kreutz, F. T Suresh, M. R. Novel bispecific immunoprobe for rapid and sensitive detection of prostate-specific antigen. Clin. Chem. 43,649-656(1997). 

NCCLS Document 1/L A 19-A. Primary reference preparations used to standardize calibration of immunochemical assays for serum prostate-specific antigen (PSA) Approved Guideline. NCCLS, Villanova, PA National Committee for Clinical Laboratory Standards (1996). 

Oesterling, J. E., Jacobson, S. J., Chute, C. G., et al. Serum prostate specific antigen in a commonly-based population of healthy men. Establishment of age-specific reference ranges. JAMA 270,860-864 (1993). 

Roehrbom, C. G Gregory, A., McConnell, J. D., et al. Comparison of three assays for total serum prostate-specific antigen and percentage of free prostate-specific antigen in predicting prostate histology. J. Urol. 48,23-32 (1996). 

Sensabaugh, G., Blake, E. Seminal plasma protein p30 Simplified purification and evidence for identity with prostate specific antigen. J. Urol. 144, 1523-1526 (1990). 

Stamey, T. A. Lower limits of detection, biological detection limits, functional sensitivity, or residual cancer detection limit/sensitivity reports on prostate-specific antigen assays mislead clinicians. Clin. Chem. 42, 849-850 (1996). 

Woodrum, D. L French, C. M., Hill, T. M et al. Analytical performance of the Tandem-R free PSA immunoassay measuring free prostate-specific antigen. Clin. Chem. 43, 1203-1208 (1997)... 

Population studies associate tomato consumption with reduced risk to prostate cancer. The most positive associations have come from cohort studies performed before the prostate-specific antigen (PSA)-screening era, and these studies have suggested that the tomato/lycopene effect was the strongest for clinically relevant prostate cancers (Giovannucci 2007). Small human studies have shown in vivo antioxidant effects for tomato products but evidence for lycopene alone is weak (Chen et al. 2001, Porrini and Riso 2000, Riso et al. 2004, Zhao et al. 2006). Animal and tissue culture studies have been... 

Note PCa, prostate cancer WM, white male DES, diethylstilbestrol AR, androgen receptor PSA, prostate specific antigen and PAP, prostatic acid phosphatase. 

Barber, NJ, X Zhang, G Zhu et al. 2006. Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study. Prostate Cancer Prostatic Dis 9 407 -13. 

Giovannucci, E. 2007. Does prostate-specific antigen screening influence the results of studies of tomatoes, lycopene, and prostate cancer risk 7 Natl Cancer Inst 99(14) 1060-1062. 

Miyata, Y, H Sakai, T Hayashi, and H Kanetake. 2003. Serum insulin-like growth factor binding protein-3/ prostate-specific antigen ratio is a useful predictive marker in patients with advanced prostate cancer. Prostate 54 125-132. 

Harma, H., Tarkkinen, P., Soukka, T., and Lovgren, T. (2000) Miniature single-particle immunoassay for prostate-specific antigen in serum using recombinant Fab fragments. Clin. Chem. 46, 1755-1761. 

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