Antacids bismuth

This macrolide can be used effectively for the treatment of nongonococcal genital infections [331, 332]. In the therapy of H. py/on-associated peptic ulcer disease, combination therapy of spiramycin, metronidazole, and antacid/bismuth resulted in ulcer healing rates of 89-91% and bacteriological eradication rates of... 

Bismuth subcarbonate [5892-10 ] (basic bismuth carbonate) is a white or pale yellow powder that is prepared by interaction of bismuth nitrate and a water-soluble carbonate. The exact composition of this dmg depends on the conditions of precipitation it corresponds approximately to the formula (Bi0)2C02. It has been widely used as an antacid (183). 

Bismuth subnitrate [1304-85-4] (basic bismuth nitrate) can be prepared by the partial hydrolysis of the normal nitrate with boiling water. It has been used as an antacid and in combination with iodoform as a wound dressing (183). Taken internally, the subnitrate may cause fatal nitrite poisoning because of the reduction of the nitrate ion by intestinal bacteria. 

A number of substances may interfere with stool examination. Particulate materials such as barium, antacids, kaolin, and bismuth compounds interfere with morphologic examination, and oily materials such as mineral oil create small, refractile droplets that make examination difficult. Antimicrobial agents, particularly broad-spectrum antimicrobial agents, may suppress amebae. If any of these substances have been used, specimens should not be submitted until the substances have been cleared (generally 5 to 10 days). A fecal specimen may appear satisfactory by gross examination when there is still barium, etc., which can interfere with microscopic examination. 

Drugs that may affect tetracyclines include antacids containing aluminum, calcium, or magnesium iron salts zinc salts barbiturates bismuth salts carbamazepine cholestyramine colestipol phenytoin rifamycins urinary alkalinizers (eg, sodium lactate, potassium citrate). 

Bismuth, discovered in 1753, has a long history of medical uses ranging from treatment of syphilis and malaria to diarrhea. More recently, antibacterial properties of bismuth-containing antacids have been used to treat peptic ulcers. In general the medical use of bismuth has declined with the advent of new drug therapies. 

Bismuth (Bi) Antacid (ulcers) Medial, consumer products Kidney damage... 

Moayyedi P, Soo S, Deeks J, Forman D, Harris A, limes M, Delaney B. Systematic review antacids, H2-receptor antagonists, prokinetics, bismuth and sucralfate therapy for non-ulcer dyspepsia. Aliment Pharmacol Ther 2003 17 1215-27. 

Salt of Salicylic Acid. A large number of salts of salicylic acid have been prepared and evaluated for therapeutic or other commercial use. Sodium salicylate has analgesic, antiinflammatory, and antipyretic activities. Magnesium salicylate, an analgesic and antiinflammatory agent, appears to have exceptional ability to relieve backaches. It is also used for the symptomatic relief of arthritis. Bismuth subsalicylate is taken orally in combination with other ingredients for protective, antacid action as well as antidiaiiheal and antiseptic effects. 

Antidiarrheal drugs, such as kaoUn-pectin and bismuth products (176,177), impair the absorption of tetracyclines by chelation (see the interaction with antacids in this monograph). 

The goals of PUD therapy are to promote healing, relieve pain, and prevent ulcer complications and recurrences. Medications used to heal or reduce ulcer recurrence include antacids. histamine H -receptor antagonists, protective mucosal barriers, proton pump inhibitors, prostaglandins, and bismuth salt and antibiotic combinations. 

Bismuth-containing antacid preparations have been in use for a long time, but some of the bismuth chelates (e.g. tripotassium dicitratobismuthate) are of proven benefit in ulcer, and, though it is not clear how they work, there is some... 

Clinically important, potentially hazardous interactions with aminophylline, amiodarone, antacids, antineoplastics, arsenic, bepridil, bismuth, bismuth subsalicylate, bretylium, calcium salts, cocoa, didanosine, disopyramide, duloxetine, erythromycin, iron, magnesium salts, meptazinol, methylxanthines, NSAIDs, phenothiazines, procainamide, quinidine, rasagiline, sotalol, sucralfate, tizanidine, tricyclic antidepressants, zinc... 

Clinically important, potentially hazardous interactions with amoxicillin, ampicillin, antacids, bacampicillin, bismuth, calcium, carbenicillin, cloxacillin, corticosteroids, digoxin, iron, methoxyflurane, mezlocillin, nafcillin, oxacillin, penicillins, piperacillin, retinoids, ticarcillin, zinc... 

Clinically important, potentially hazardous interactions with aluminium, antacids, anticoagulants, bismuth, calcium, diuretics, iron preparations, magnesium, oral contraceptives, oral retinoids, quinapril... 

Many types of bismuth mineral salts (e.g., bismuth subsalicylate) are generally multipurpose intestinal medicinal agents. As an antisecretory agent, bismuth subsalicylate coats and protects irritated and inflamed intestinal lumen tissue (antiulcer actions), decreases the secretion of fluid into the intestine, absorbs or neutralizes bacterial toxins, inhibits any bacterial activity (antidiarrhea actions), and also increases alkaline secretion to counteract any acid production (antacid action). Thus, this agent controls the frequent voluminous loss of watery stools while relieving intestinal cramping and irritation. 

Amoxicillin, clarithromycin, tetracycline, and metronidazoie have been used in various regimens for H. fy/on-associated GI ulcers, together with H2 blockers, proton pump inhibitors, and antacids e.g., "BMI" regimen bismuth, metronidazole, and tetracycline. 

T Healing and 4 ulcer recurrence. Sucralfate requires acid pH—antacids may interfere. Bismuth subsalicylate is also protective. 

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