Antisecretory agents

I The cornerstone of rotavirus treatment is supportive care and rehydration with ORT or intravenous fluids if necessary. Antimotility and antisecretory agents should not be used... 

Volume I). The most rapid metabolic deactivating reaction is oxidation to the bioinert C15 oxo prostaglandins. Converting the latter to a tertiary methyl carbinol led to the desired orally active gastric antisecretory agents. 

Because the development of antibiotic resistance will continue to be a problem, the development of effective alternative treatments is imperative. Immunization, probiotics, antisecretory agents, improved oral rehydration and nutrition therapy and nonabsorbable antibiotics are being considered by clinicians and researchers. Novel... 

Quadruple therapy regimens (2 antibiotics, bismuth, antisecretory agent) Like triple therapy regimens, these have proven to be effective in H. pylori eradication. The primary disadvantage of these regimens is compliance. In addition, because of the variety and number of medications used, adverse effects are more common in... 

Maintenance therapy with antisecretory agents Currently, it is advisable to continue maintenance until H. pylori cure has been confirmed in patients with a history of complications, frequent or troublesome recurrences or refractory ulcers. 

Metoclopramide is available for clinical use in the USA domperidone is available in many other countries. These agents are sometimes used in the treatment of symptomatic GERD but are not effective in patients with erosive esophagitis. Because of the superior efficacy and safety of antisecretory agents in the treatment of heartburn, prokinetic agents are used mainly in combination with antisecretory agents in patients with regurgitation or refractory heartburn. 

Atropine Generic Peptic ulcer, irritable bowel syndrome, neurogenic bladder, bronchospasm, preoperative antisecretory agent, cardiac arrhythmias (e.g., sinus bradycardia, postmyocardial infarction, asystole], reversal of neuromuscular blockade, antidote to cholinesterase inhibitor poisoning... 

Glycopyrrolate Robinul Peptic ulcer, preoperative antisecretory agent, antidiarrheal, reversal of neuromuscular blockade... 

Hyoscyamine Cystospaz, Levsin, others Peptic ulcer, irritable bowel syndrome, urinary bladder hypermotility, preoperative antisecretory agent... 

Scopolamine Transderm-Scop, others Motion sickness, preoperative antisecretory agent, postoperative nausea and vomiting, antivertigo... 

Sachs and his colleagues had begun work that would show that H+/K+-ATPase, as the proton pump, moves acid across the membranes of gastric parietal cells (Blum et al, 1971). Scientists at the Swedish firm had focused on imidazoles and specifically, benzimidazoles, apparently in part because cimetidine (like histamine) is an imidazole. By adding a benzimidazole moiety to pyridine-2-thioacetamide, a known antisecretory agent, a new class of substituted benzimidazoles, which would later yield omeprazole was created (Fellenius, 1981). These congeners were sufficiently novel so that patent approval, a necessary component of the project, was likely if the compounds proved useful. 

Katz et al. (1987) described a five-day test to predict the long-term effects of gastric antisecretory agents on serum gastrin in rats. 

Katz LB, Schoof RA, Shriver DA (1987) Use of a five-day test to predict the long-term effects of gastric antisecretory agents on serum gastrin in rats. J Pharmacol Meth 18 275-282 Larsson H, Carlsson E, Mattsson H et al. (1986) Plasma gastrin and gastric enterochromaffin-like cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomized rats. Gastroenterology 90 391-399... 

Tritiozine is a non-anticholinergic, antisecretory agent. It has been associated with drowsiness and occasional slight increases in transaminases (1). 

A Famotidine, as well as some of the other antisecretory agents, can lead to headaches, dizziness, and other CNS side effects. This is particularly true in older patients or in those with compromised renal elimination. 

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