Antacid aluminum-containing

Antacids Antacids are simple physical agents that react with protons in the lumen of the gut. Some antacids (aluminum-containing antacids) may also stimulate the protective functions of the gastric mucosa. The antacids effectively reduce the recurrence rate of peptic ulcers when used regularly in the large doses needed to significantly raise the stomach pH. 

Aluminum-containing antacids—constipation, intestinal impaction, anorexia, weakness, tremors, and bone pain... 

Never take these dru with aluminum-containing antacids. If antacids are required, take them 2 to 3 hours after ursodiol. 

Figure 9. Stabilizing effect of methylcellulose on foams generated by a suspension of effervescent antacid granules containing magnesium trisilicate and aluminum hydroxide...

Medications (analgesics, anticholinergerics, calcium channel blockers, clonidine, diuretics, phenothiazines, tricyclic antidepressants, iron supplements, calcium- and aluminum-containing antacids)... 

Antacids (various) 15-30 mL or 250 mg-1.5 g First-line agent (avoid aluminum-containing preparations)... 

During lactation, sucralfate maybe the best choice for treatment of heartburn because it is not absorbed systemically.25 If symptoms are not controlled, the H2 blockers are acceptable alternatives.14,25 Avoid aluminum-containing antacids during lactation owing to reports of aluminum toxicity in otherwise healthy infants.22... 

Table III. Effect of Small and Large Doses of Aluminum-Containing Antacids on Calcium Metabolism...

Calcium c/frafe. Avoid concurrent aluminum-containing antacids. 

Milk-alkali syndrome Milk-alkali syndrome, an acute illness with symptoms of headache, nausea, irritability, and weakness, or a chronic illness with alkalosis, hypercalcemia and, possibly, renal impairment, has occurred following the concurrent use of high-dose calcium carbonate and sodium bicarbonate. Hypophosphatemia Prolonged use of aluminum-containing antacids may result in hypophosphatemia in normophosphatemic patients if phosphate intake is not adequate. 

Drugs that may be affected by sucralfate include aluminum-containing antacids, anticoagulants, diclofenac, digoxin, histamine H2 antagonists (eg, cimetidine,... 

Isoniazid is water soluble and is well absorbed when administered either orally or parenterally. Oral absorption is decreased by concurrent administration of aluminum-containing antacids. 

Do not take ranitidine within 1 hour of magnesium- or aluminum-containing antacids... 

Do not take antacids (aluminum, calcium, or magnesium-containing) or iron within 2 hr of taking trovafloxacin. Take at bedtime or with food to minimize dizziness associated with trovafloxacin. Avoid excessive sunlight during treatment... 

Spencer, H., Kramer, L., Norris, C. and Osis, D. 1982B. Effect of small doses of aluminum-containing antacids on calcium and phosphorus metabolism. Am. J. Clin. Nutr. 36, 32-40. 

The primary antacids can be classified as aluminum-containing, magnesium-containing, calcium carbonate-containing, sodium bicarbonate-containing, or a combination of any of these classifications. These drugs are typically taken orally, either as tablets or as a liquid oral suspension. 

No studies were located regarding developmental effects of various forms of aluminum following acute-or chronic-duration oral exposure in healthy humans. The only human data on developmental effects come from infants with renal failure and premature infants. Their responses are probably not indicative of responses expected in normal infants. Osteomalacia and increased bone and serum levels of aluminum were reported in 3 infants with kidney failure who had been treated orally with more than 100 mg of Al/kg/day as aluminum hydroxide from the first or sixth month of life (Andreoli et al. 1984 Griswold et al. 1983), and in healthy infants ingesting aluminum-containing antacids (Pivnick et al. 1995). 

Death. Aluminum is not thought to be life-threatening to healthy humans. Studies of people receiving extremely high doses of oral aluminum in antacids have not shown any human deaths from aluminum. However, in the past, aluminum-related deaths have been reported for persons with renal disease dialyzed with aluminum -containing solutions, uremic patients exposed to dietary aluminum hydroxide to treat hyperphosphatemia and sodium citrate to correct metabolic acidosis (Kirschbaum and Schoolwerth 1989), and workers exposed by inhalation to fine powders of aluminum metal. Only very large doses (hundreds of mg/kg) of aluminum cause death in laboratory animals. 

Sakhaee K Aluminum absorption - effects of calcium citrate on aluminum-containing antacids University of Texas SW Med. Center National Center for Research Resources... 

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