Tablets disintegrants

The crospovidones are easily compressed when anhydrous but readily regain their form upon exposure to moisture. This is an ideal situation for use in pharmaceutical tablet disintegration and they have found commercial appHcation in this technology. PVP strongly interacts with polyphenols, the crospovidones can readily remove them from beer, preventing subsequent interaction with beer proteins and the resulting formation of haze. The resin can be recovered and regenerated with dilute caustic. 

Tablet-disintegration tests consist of cychcal immersion in a suitable dissolving fluid of pharmaceutical tablets contained in a basket. Acceptable tablets disintegrate completely by the end of the specified test period United State.s Fharmacopeia, 17th rev.. Mack Pub. Co., Easton, Pa., 1965, p. 919).

Sodium alcohol sulfates are also used in the formulation of synthetic soaps and paste hand cleaners, commonly together with other surfactants and as tablet disintegrators in the case of sodium dodecyl sulfate. Sodium, but preferably ammonium and alkanolamine salts, is also used in liquid soaps. 

Mirtazapine Remeron Yes Tablet, disintegrating tablet (SolTab) 15 15-45 Once daily... 

Fig. 9 Effect of starch concentration and location on tablet disintegration time. (From Ref. 54.)...

Water uptake has been implicated as a mechanism of action for tablet disintegrants. Khan and Rhodes studied the adsorption and absorption properties of various disintegrants [56]. They concluded that the... 

MOLECULAR STRUCTURE. In their attempts to identify the mechanism(s) of action of tablet disintegrants, researchers recently have turned their... 

Garlic supplements - powder tablets or capsules, steam-distilled oil, vegetable oil macerate extract, or extract aged in dilute alcohol - are widely available and are taken by millions. Since the active principle, allicin, is not present in garlic bulb, the supplements rely on the presence of precursor alliin and enzyme alliinase. In tests on 24 commercial brands of enteric-coated tablets, all except one gave low dissolution allicin release 83% of the brands released less than 15% of their potential allicin.78,79 Relevant factors were impaired enzyme activity caused by excipients and slow tablet disintegration. Caveat emptor ... 

Studies have shown that the pore size distribution can influence liquid penetration into tablets [28,29,52]. The accessibility of water vapor to tablet components has been related to chemical stability, especially in the case of hydrolyzable drugs [28]. Solvent penetration, which can affect tablet disintegration and dissolution, has been related to pore size [52]. 

Abrahamsson B, Albery T, Eriksson A, Gustafsson I, Sjoberg M (2004) Food effects on tablet disintegration. Eur J Pharm Sci 22 165-172... 

Although water penetration is a neeessary first step for disintegration, swelling is probably the most widely aceepted mechanism of action for tablet disintegrants. Indeed, most disintegrants do swell to some extent, but the variability of this property between disintegrants reduces its plausibility as a sole meehanism. 

Carstensen, J.T., and Chowan, Z.T., Correlation between tablet disintegration and in vitro dissolution, Drug Dev. Ind. Pharm., 6 569-571 (1980). 

Nogami, H., Fukuzawa, H., and Nakai, Y., Studies on tablet disintegration. I. The effect of penetrating rate on tablet disintegration, Chem. Pharm. Bull., 11 1389-1398 (1963). 

Lerk, C.F., Bolhuis, G.K., Smallenbroek, A.J., and Zuurman, K., Interaction of tablet disintegrants and magnesium stearate during mixing. 11. Effect on dissolution rate, Pharm. Acta Helv., 57 282-286 (1982). 

Caramella, C, Columbo, P., Conte, U., and LaManna, A., Swelling of disintegrant partieles and disintegrating force of tab eC,Labo-Pharma. Probl. Tech., 32 115-119 (1984). Caramella, C., Columbo, P., Conte, U., and LaManna, A., Tablet disintegration update The dynamie approach, Drwg Dev. Ind. Pharm., 13 2111-2145 (1987). 

Brzeczko, A.W., Ph.D. Dissertation, A Critical Evaluation of Tablet Disintegration Processes, University of Maryland, Baltimore, 1989, pp. 129-172, 237-255. 

Shah, N.H., Bekersky, 1., and Jarowski, C.I., Carboxymethylcellulose Effect of the degree of polymerization and substitution on tablet disintegration and dissolution. 111. Urinary salicylate from rapid and controlled release formulas. In Program and Abstracts, APhA. Acad. Pharm. Sci. Mtg., IPT Section, Nov. 17, 1983, American Pharmaceutical Assoc., Washington, D.C., 1983, pp. 34, 35. 

Rizk, S., Barthelemy, C., Duru, C., and Guyot-Hermann, A.M., Investigation on a new modified USP Xanthan with tablet-disintegrating properties. Drug Dev. Ind. Pharm., 23 19-26 (1997). 

Disintegrant Aids tablet disintegration in Starch, sodium starch gtycoUate, cross-linked... 

Immediately upon opening the blister, using dry hands, remove the tablet and place it in the mouth. Tablet disintegration occurs rapidly in saliva so it can be easily swallowed with or without water. 

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