Fast dissolving/disintegrating tablets

DuraSolv is Cima s second-generation fast-dissolving/disintegrating tablet formulation and is also produced using direct compression but using higher compaction... 

Tablets fast dissolving, lipid-carrier based, slow releasing, disintegrate without water, float in the stomach (gastric retentive), buccal... 

Fast-disintegration technology is used for manufacturing these tablets. The advantages of fast-dissolving tablets are as follows ... 

P.R. Rai, A. Tiwary, and V. Rana, Superior disintegrating properties of calcium cross-linked Cassia fistula gum derivatives for fast dissolving tablets, Carbohydr. Polym., 87 (2), 1098-1104,2012. 

Heptakis (2,6-di-0-methyl)-fi-cyclodextrin (DMCD). Solinis et al. [60] used hydrophilic DMCD along with HPMC (in six of nine tablet formulations), with the presumption that the aromatic ring of the drug could increase the possibility of stereoseleetive interaetion between salbutamol enantiomers and DMCD. However, stereoseleetive release or interaetion was not observed. In the capillary electrophoresis, in whieh DMCD was added to the buffer, resolution of the enantiomers was noted. In these formulations, cyclodextrins tend to dissolve quickly or disintegrate the matrix too fast to allow for diffusion or enantioselective drug release to take place. 

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