Tablet evaluation disintegration testing

Determination of the time for a tablet to disintegrate when immersed in some test fluid has been a requirement in most compendia for many years. For many years, it was the only test available to evaluate the release of medicaments from a dosage unit. We now recognize the severe limitations of such tests in assessing this property—hence, the introduction of dissolution rate requirements. 

Both chemical and physical properties have to be considered when evaluating effervescent products. In this review, only the physical properties will be discussed, except where the chemical characteristics are especially influenced by the effervescent base. For more detail, Ph. Eur. includes a special disintegration test for effervescent tablets and granules. ... 

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