Orally disintegrating tablets products

Tokuyama, E., Matsunaga, C., Yoshida, K., Mifsud, J.-C., Irie, T., Yoshida, M., and Uchida, T. (2009). Famotidine orally disintegrating tablets Bitterness comparison of original and generic products. Chem. Pharm. Bull. 57(4), 382-387. 

Excipients are sub-divided into various functional classifications, depending on the role that they are intended to play in the resultant formulation, for example, fillers, disintegrants, binders, lubricants and glidants. An added complexity is the fact that certain excipients can have different functional roles in different formulation types. Thus, lactose is widely used as a filler or diluent in solid oral dosage forms, for example, tablets and capsules [2] and as a carrier for inhalation products [3]. 

Lubrication is an important unit operation in manufacturing solid oral dosage forms, particularly when using a direct compression platform. Pharmaceutical lubricants can have a significant impact on product performance (e.g., disintegration and dissolution) as well as manufacturability. Lubrication is one of the most critical aspects of a tablet formulation. A lubricant is intended to reduce the friction between the tablet surface and die wall during and after compaction to enable easy ejection of the tablet. In low-dose dmg product development, three issues are associated with lubricating a direct compression formulation ... 

Systemic drug absorption from a drug product consists of a succession of rate processes (Fig. 2). For solid oral, immediate release drug products (e.g., tablet, capsule), the rate processes include 1) disintegration of the drug product and subsequent release of the drug 2) dissolution of the drug in an aqueous environment and 3) absorption across cell membranes into the systemic circulation. In the... 

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