Stomach carcinoma

The nonribosomal cyclic peptide leucamide A, 352, was isolated from the marine sponge Leucetta microraphis from the Great Barrier Reef of Australia <2002JOC4989, 2002JOC1636>. It was isolated as the principal active component and found to inhibit the growth of three tumor cell lines (stomach carcinoma, liver carcinoma, liver carcinoma with mutated p53). The compound is composed of seven amino acids and amino-acid-derived residues L-leucine, oxazole, L-alanine, methyloxazole, thiazole, L-valine, and L-proline. 

Familial adenomatous polyposis Malignant lymphoma Stomach carcinoma Colon adenocarcinoma... 

Dorant E, van den Brandt PA, Goldbohm RA, et al. Consumption of onions and a reduced risk of stomach carcinoma. Gastroenterology 1996 110 12-20. 

A-431 (epidermoid carcinoma) OKK (maxillary gland carcinoma) KATO-III (stomach carcinoma) KB (oral carcinoma) WiDr (colon adenocarcinoma) 1-407 (normal embryonic intestine) A-22 (arachnoid) NY (osteosarcoma) T-2346 (meningeoma) T-24 (bladder carcinoma) HLEC-1 (liver carcinoma)... 

Helicobacter pylori bacteria (chronic gastritis and stomach carcinoma)... 

On the other hand, a negative association was observed between tea drinking and stomach carcinomas (Stocks, 1970) and coffee consumption and, for example, kidney cancers (Jacobsen and Bjelke, 1982). 

Inhibitory effect on carcinogenesis Benzo(a)pyrene-induced stomach carcinomas... 

Bronchogenic carcinoma and mesothelioma of the pleura and peritoneum are causally associated with asbestos exposure excesses of cancer of the stomach, colon, and rectum have also been observed. Among 632 asbestos workers observed from 1943 to 1967, there... 

In a study of carcinogenesis, DBCP was orally administered to rats and mice 5 times/week at maximally tolerated doses and at half those doses. ° As early as 10 weeks after initiation of treatment, there was a high incidence of squamous cell carcinomas of the stomach in both species. In female rats there were also mammary adenocarcinomas. Chronic inhalation resulted in carcinomas of the respiratory tract in mice and multiple site tumors in rats. ... 

In a carcinogenic study, male and female rats were given DMHP by gavage 5 days/week for 103 weeks. At 200mg/kg, there were increases in alveolar/bronchiolar carcinomas, squamous cell carcinomas of the lung, and carcinomas of the stomach in male rats. Neoplastic lesions did not occur in mice after similar treatments. Species-dependent differences in the metabolism of DMPH were limited to more rapid metabolism and elimination by mice compared with rats. Therefore, the... 

It has been postulated that wood dust carcinoma results from a multistep process Exposure causes loss of cilia and hyperplasia of the goblet cells and initiation of cuboidal cell metaplasia, followed (after a quiescent period) by squamous cell metaplasia. Decades later, cellular aplasia leads to nasal adenocarcinoma. The time between first occupational exposure to wood dust and the development of nasal cavity adenocarcinoma averages 40 years. Other cancers, including lung cancer, Hodgkin disease, multiple myeloma, stomach cancer, and colorectal cancer and lymphosarcoma, have been mentioned in relation to wood... 

Fluorouracil is used to treat carcinomas of the head, neck, colon, rectum, breast, stomach, bladder, pancreas, and for actinic and solar creatitis. Synonyms of this drug are efQu-derm, fludix, fluoroblastin, arumel, benton, lifril, and others. 

Decubitus ulcer (e.g. bed sores, pressure sores) Diabetic ulcers Varicose ulcers Rodent ulcers Peptic ulcers Ulcer due to continuous pressure exerted on a particular area of skin often associated with bed-ridden patients Ulcers (e.g. diabetic leg ) caused by complications of diabetes Due to defective circulation, sometimes associated with varicose veins An ulcerous cancer (basal cell carcinoma), usually affecting the face Ulcer of the digestive tract, caused by digestion of the mucosa by acid and pepsin may occur in e.g. the duodenum (duodenal ulcer), or the stomach (gastric ulcer)... 

Fluorouracil is used in several combination regimens in the treatment of breast cancer. It also has palliative activity in gastrointestinal adenocarcinomas, including those originating in the stomach, pancreas, liver, colon, and rectum. Other tumors in which some antitumor effects have been reported include carcinomas of the ovary, cervix, oropharynx, bladder, and prostate. Topical 5-fluorouracil cream has been useful in the treatment of premalignant keratoses of the skin and superficial basal cell carcinomas, but it should not be used in invasive skin cancer. 

Doxorubicin is one of the most effective agents used in the treatment of carcinomas of the breast, ovary, endometrium, bladder, and thyroid and in oat cell cancer of the lung. It is included in several combination regimens for diffuse lymphomas and Hodgkin s disease. Doxorubicin can be used as an alternative to daunorubicin in acute leukemias and is useful in Ewing s sarcoma, osteogenic sarcoma, soft-tissue sarcomas, and neuroblastoma. Some activity has been reported in non-oat cell lung cancer, multiple myeloma, and adenocarcinomas of the stomach, prostate, and testis. 

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