Adenocarcinomas, mammary

The tumoricidal activity of MRAMs containing either doxorubicin or protein A, a constituent of the cell wall of Staphylococcus aureus, was tested in rats with induced mammary adenocarcinoma (138). 

N2. Neri, A., Bohoslawec, O., Anderson, T. D., and Tokes, Z. A., Differential release of active proteinase inhibitors by 2 rat mammary adenocarcinoma variants possessing different metastatic potentials. Cancer Res. 51, 1318-1325 (1991). 

Fig. 2.4 Therapeutic effect of dEpoB and padi-taxel (Taxol ) in nude mice bearing MCF-7/Adr xenografts following Q2D x 5, i.v. treatment. Adriamycin (DX)-resistant human mammary adenocarcinoma (MCF-7/Adr) tissue 50 mg was implanted subcutaneously into nude mice on day 0. Six-hour i.v. infusions for control, dEpoB and paditaxel and i.v. injection for VBL, DX, and VP-16 were given on days 8,10,12,14 and 16. o, control with vehicle only to, VBL,...

Gabor, H., and Abraham, S., 1986, Effect of dietary menhaden oil on tumor ceU loss and the accumulation of mass of a transplantable mammary adenocarcinoma in BALB/c mice, J. Natl. Cancerinst. 76 1223-1229. 

There was a statistically significant compound-related increase in incidence of several other tumors in female mice hemangiosarcoma of the abdominal retropehtoneum, particularly involving the area of the ovaries, uterus, kidneys, and adrenal subcutaneous fibrosarcomas and mammary adenocarcinoma (NTP 1982). A limitation of the study was poor survival in male mice from ascending suppurative urinary tract infections. 

In another rat study, 3,3 -diehlorobenzidine was administered to 50 male (70 mg/kg/day) and 50 female (80 mg/kg/day) Sprague-Dawley rats, in a standard diet for up to 16 months (Stula et al. 1975). In rats fed 3,3 -diehlorobenzidine in the diet for a total of 349 days (females) and 353 days (males), histopathologieal evaluations revealed mammary adenocarcinoma (16% incidence), malignant lymphoma (14%), granuloeytie leukemia (20%), carcinoma of the Zymbal gland (18%) in males, and mammary adenocareinoma (59%) in females. These tumors were either totally absent or occurred statistically less frequently in untreated controls. The authors noted that most of these tumors appeared to arise in the bone marrow and hematopoietic foci in the spleen and liver with subsequent metastasis to other organs. Only one dose level was used in the study, however, and information on the prrrity of the test substance was not provided. 

Taken together, the various observations suggest that FBXLIO has context-dependent pro- and anti-oncogenic activities. In line with this, FBXLIO expression was reported to be significantly decreased in human glioblastomas relative to normal brain tissue [54], while FBXLIO was found to be overexpressed in lymphomas and mammary adenocarcinomas [56]. 

In a study of carcinogenesis, DBCP was orally administered to rats and mice 5 times/week at maximally tolerated doses and at half those doses. ° As early as 10 weeks after initiation of treatment, there was a high incidence of squamous cell carcinomas of the stomach in both species. In female rats there were also mammary adenocarcinomas. Chronic inhalation resulted in carcinomas of the respiratory tract in mice and multiple site tumors in rats. ... 

There was also a dose-related trend for the incidence of hemangiosarcomas and mammary adenocarcinomas in female rats and hepatocellular carcinoma in male mice. High mortality in all animal groups obscured results. The National Cancer Institute determined that there was no conclusive evidence for carcinogenicity, but 1,1-dichloroethane should be treated with caution by analogy to other chloroethanes shown to be carcinogenic in laboratory animals. ... 

Oral famciclovir is generally well tolerated, although headache, diarrhea, and nausea may occur. As with acyclovir, testicular toxicity has been demonstrated in animals receiving repeated doses. However, men receiving daily famciclovir (250 mg every 12 hours) for 18 weeks had no changes in sperm morphology or motility. The incidence of mammary adenocarcinoma was increased in female rats receiving famciclovir for 2 years. 

Carbon tetrachloride was tested for carcinogenicity in several experiments in mice by oral and intrarectal administration and in rats by oral and subcutaneous administration and by inhalation exposure it was also tested in one experiment in hamsters and one experiment in trout by oral administration. In various strains of mice, it produced liver tumours, including hepatocellular carcinomas. In various strains of rats, it produced benign and malignant liver tumours and in one experiment with subcutaneous injection, an increased incidence of mammary adenocarcinomas was observed. In hamsters and trout, increased incidences of liver tumours were observed however, these studies were considered to be inadequate (lARC 1979). 

Methylaziridine was administered to male and female rats by gavage at doses of 0, 10 and 20 mg/kg bw. Treatment-related toxicity was found at both doses and increased mortality was seen at the high dose, which was discontinued after 28 weeks. Animals were killed at week 60. The treatment produced mammary adenocarcinomas in females at both doses, gliomas in both sexes at both doses, squamous-cell carcinomas of the ear duct in both sexes, leukaemia in males and a small number of intestinal tumours in males (lARC, 1975 Weisburger etal., 1981). 

Oberlies, N.H., Chang, C.-J., and McLaughlin, J.L. Structure activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr).. Med. Chem., 40, 2102, 1997a. 

Charo, J., Ciupitu, A.M., Le Chevalier De Preville, A., Trivedi, P., Klein, G., Uinkula, J. and Kiessling, R. (1999) A long-term memory obtained by genetic immunization results in full protection from a mammary adenocarcinoma expressing an EBV gene. J. Immunol, 163, 5913-5919. 

Oshikawa, K., Shi, F., Rakhmilevich, A.L., Sondel, P.M., Mahvi, D.M. and Yang, N.-S. (1999) Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using interleukin-12, pro-interleukin-18 andIL-1 -converting enzyme cDNA. Proc. Natl. Acad. Sci. USA, 96, 13351-13356. 

Some inhibitory activity of gossypol against mouse mammary adenocarcinoma 755 and borderline activity against leukaemia P388 were reported [323, 324], The effective dose range of gossypol is rather narrow because of toxicity [324]. Gossypol has recently been found to be a specific inhibitor of DNA polymerase a [325], a major enzyme involved in DNA replication. This compound may also interfere with the DNA repair process [325]. 

Fritsche, K.L. and Johnston, P.V. 1990. Effect of dietary a-linolenic acid on growth, metastasis, fatty acid profile and prostaglandin production of two murine mammary adenocarcinomas. J. Nutr. 

Finally, an interesting example has been reported in the syntheses of new photoreactive neoglycolipid probes carrying carbohydrate determinants specific for some murine mammary adenocarcinoma cells for the study of lectin receptors on tumor cell surfaces.71... 

The primary adverse effect of intravenous cidofovir is a dose-dependent nephrotoxicity. Concurrent administration of other potentially nephrotoxic agents (eg, amphotericin B, aminoglycosides, nonsteroidal anti-inflammatory drugs, pentamidine, foscarnet) should be avoided. Prior administration of foscarnet may increase the risk of nephrotoxicity. Other potential side effects include uveitis, decreased intraocular pressure, and probenecid-related hypersensitivity reactions. Neutropenia and metabolic acidosis are rare. The drug caused mammary adenocarcinomas in rats and is embryotoxic. 

Rat (Sprague- Dawley) once Gd 15 (GO) 1 F (alteration in mammary gland differentiation in 50-day old pups increased number of chemically-induced mammary adenocarcinomas in pups)... 

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