Ulcer duodenal

Prior to this work, dietary fiber, of which ceUulose is oae of the more important constituents, was considered important primarily as a means of preventing or overcoming constipation. Otherwise, dietary fiber was considered to be a metaboHcally iaert substance. A large variety of diseases such as appendicitis, hiatus hernia, gallstones, ischemic heart disease, diabetes, obesity, dental caries, and duodenal ulcers are now suspected to be associated with the consumption of a highly refined diet (42). 

The mechanism by which sucralfate accelerates healing of duodenal ulcers has not been determined. It does not have significant antisecretory, acid neutralizing activity or direct stimulation of ulcer healing. It is known that the mechanism is local rather than systemic. Binding of pepsin or bile salts may contribute to its effect. It is indicated for the short-term therapy of active duodenal ulcers and for maintenance at reduced dosage. 

Magnesia and aluminum suspension is useflil for the therapy of duodenal ulcers when given at high doses at frequent intervals. It is available in both hquid and tablet formulations. 

Tripotassium dicitratobismuthate [57644-54-9] (bismuth subcitrate), De-Nol is a buffered aqueous suspension of a poorly defined, water-insoluble bismuth compound. It is said to very effective for the treatment of gastric and duodenal ulcers (180,184). There have not yet been any reports of bismuth encephalopathy following the use of this dmg. 

Gl pain, headache, dizziness, somnolence, insomnia, rash Dizziness, tiredness, nausea, dyspepsia, rash, constipation, bleeding, diarrhea Dizziness, visual disturbances, headache, nausea, vomiting, gastric or duodenal ulcer formation, Gl bleeding... 

Nausea, vomiting, diarrhea, drowsiness, gastric or duodenal ulcer formation, Gl bleeding Same as celecoxib... 

Nausea, diarrhea, abdominal cramps, H. pylori with duodenal ulcer Ulcerative colitis... 

Maintenance of remission of ulcerative colitis in patients intolerant of sulfasalazine Active duodenal ulcer... 

These drug are used for the medical treatment of agastric or duodenal ulcer, gastric hypersecretory (excessive gastric secretion of hydrochloric acid) conditions, and GERD. These drug may also be used as prophylaxis of stress-related ulcers and acute upper GI bleeding in critically ill patients. 

The proton pump inhibitors are particularly important in the treatment of Helicobacter pylori in patients with active duodenal ulcers. Helicobacter pylori (H. pylori) has been implicated as a causative organism in a type of chronic gastritis and in a large number of cases of peptic and duodenal ulcers. 

The proton pump inhibitors are used for treatment or symptomatic relief of various gastric disorders, including gastric and duodenal ulcers, GERD, or pathological hypersecretory conditions. Painful, persistent heartburn 2 or more days a week may indicate acid reflux disease which can erode the delicate lining of the esophagus,... 

TABLE 48-1 Agents Used to Treat H. Pylori in Patients With Duodenal Ulcers... 

DRUG USE FOR ERADICATION OF H. PYLORI IN PATIENTS WITH DUODENAL ULCER DOSAGE RANGE... 

Bismatrol) biS-muth sub-sa-li -s-late with duodenal ulcer with at least two anti-infectives... 

Bismudi subsalicylate is used in combination witii otiier dru > to treat gastric and duodenal ulcers caused by H. pylori bacteria Mesalamine is used in the treatment of chronic inflammatoiy bowel disease Misoprostol is used to prevent gastric ulcers in those taking aspirin or nonsteroidal anti-inflammatory dragp in high doses for a prolonged time Olsalazine is used in the treatment of ulcerative colitis in those allergic to sulfasalazine. Sulfasalazine is used in the treatment of Crohn s disease and ulcerative colitis. Sucralfate is used in the treatment of duodenal ulcer. 

The primary health care provider has prescribed cime-tidine for the treatment of a duodenal ulcer in Mr. Talley, who is 68 years old. A drug history by the nurse reveals that Mr. Talley is also taking the following drugs Lanoxin 0.5 mg orally each day and a daily aspirin tablet. Analyze this situation. Discuss what you would tell Mr. Talley. 

Excessive secretion of gastric acid, associated with Helicobacter pylori infection, can result in the development of gastric and duodenal ulcers small changes in the composition of bile can result in crystallization of cholesterol as gallstones failure of exocrine pancreatic secretion (as in cystic fibrosis) leads to undernutrition... 

Salim (1992d) has performed several studies using reser-pine to produce a chronic model of peptic ulceration in rats. Administration of allopurinol, DMSO, cysteine or methionine-S-methylsulphonium chloride protected against injury. In addition allopurinol and DMSO were found to stimulate healing in this model. In an acute model of duodenal ulceration induced by pentagastrin and carbachol allopurinol, DMSO, cysteine or methionine-S-methylsulphonium chloride all protected against injury. 

Davies, G.K, Simmonds, N.J., Stevens, T.R.J., Grandison, A., Revell, P., Blake, D.R. and Rampton, D.S. (1992a). Mucosal reactive oxygen metabolite production in duodenal ulcer disease. Gut 33, 1467-1472. 

Salim, A.S. (1990c). Oxygen-derived free radicals and the prevention of duodenal ulcer relapse, a new approach. Am. J. Med. Sci. 300, 1-6. 

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